Banca de DEFESA: GEORGE HARISSON FELINTO SAMPAIO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : GEORGE HARISSON FELINTO SAMPAIO
DATE: 25/04/2023
TIME: 09:00
LOCAL: REMOTA - https://meet.google.com/icn-wihg-yjw
TITLE:

EPIDEMIOLOGICAL PROFILE OF ACUTE CHAGAS DISEASE IN NORTHERN BRAZIL AND EVALUATION OF ENTOMOLOGICAL SURVEILLANCE OF VECTORS OF Trypanosoma cruzi IN AREAS OF THE BRAZILIAN NORTHEAST.

KEY WORDS:

Trypanosoma cruzi; Triatomines; Oral transmission; Retrospective Study; Public Health 

PAGES: 76
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Introduction: The spread of Trypanosoma cruzi infection is directly related to its form of transmission and the primordial control actions are those that prevent or hinder the contact of the parasite with humans and domestic animals. For this, it is essential to understand the socioepidemiological characteristics of each region, so that specific measures are established for each cycle of transmission of the parasite. Objective: To determine the epidemiological profile of individuals with suspected acute Chagas disease in northern Brazil and to evaluate the entomological control of T. cruzi vectors in an endemic area of the state of Rio Grande do Norte. Methods: The epidemiological profile of individuals with suspected acute Chagas disease (ACD) was evaluated in the municipality of Breves, Pará State (PA), Brazil. The data obtained by DATASUS-Municipal Health Department were used from 2007 to 2017 and analyzed using simple descriptive statistics. The entomological data analysis was performed in the Agreste mesoregion of the state of Rio Grande do Norte, regarding entomological surveillance for the period from 2005 to 2015 and made available by the State Department of Public Health of the State of Rio Grande do Norte. The evaluation of the activities was carried out through the active search for triatomines in the housing units and the chemical control of these infested dwellings. The quantitative analysis of household units surveyed on the entomological indicators was performed using the random effects linear regression test (p <0.05). Results: The analysis of the epidemiological profile of individuals with suspected ACD in the municipality of Breves, PA, showed that the majority of them were male (54.7%-145/265), aged between 10 and 19 years (23%-61/265), low education level (74.4%-197/265) and residents in rural areas (58.9%-156/265). A total of 265 individuals were reported as suspected cases of ACD, of which 64.1% (170/265) had laboratory confirmation for chagasic infection. The main route of transmission of T. cruzi was oral (98.1%-260/265), probably through the consumption of food contaminated with viable forms of the parasite. This route of contamination occurred mainly in the domiciliary environment (96.2%-255/265) with higher incidence between the months of August and December. From 2005 to 2015, 92,156 household units were investigated in the rural mesoregion of RN and the presence of triatomines was recorded in 4,639 (5.0%). Only 53.1% (2,463/4,639) of the infested household units were submitted to chemical control. In addition, there was a decrease in the total number of units surveyed over time associated with an increase in the index of intradomiciliary colonization (p = 0.004). A total of 4,653 specimens of triatomines were captured and the species recorded were Triatoma pseudomaculata (n = 1,775), Triatoma brasiliensis (n = 1,569), Rhodnius nasutus (n = 741) and Panstrongylus lutzi (n = 568), with natural infection index by T. cruzi of 2.2% (90/4,104). Conclusões: The results showed that oral transmission of T. cruzi has become increasingly high in the northern region of Brazil, highlighting the need to implement actions aimed at health education as strategies to ensure the improvement of food handling practices in natura. In addition, we identified that entomological surveillance in the Agreste mesoregion of the state of RN was discontinued and, the data signal for more effective and continuous public policies, mainly regarding the chemical control of vectors to avoid exposure of domestic animals and humans to the risk of acquiring infection by T. cruzi.

COMMITTEE MEMBERS:
Externa ao Programa - 1375489 - ANA CLAUDIA GALVAO FREIRE GOUVEIA - nullExterna à Instituição - ANA MARIA DE CASTRO - UFG
Presidente - ***.985.294-** - LUCIA MARIA DA CUNHA GALVAO - UFRN
Externa ao Programa - 3270997 - NATHALIE DE SENA PEREIRA - nullExterno à Instituição - RITA DE CASSIA MOREIRA DE SOUSA - FIOCRUZ-MG