Banca de DEFESA: JOELMA DANTAS MONTEIRO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOELMA DANTAS MONTEIRO
DATE: 19/12/2022
TIME: 09:00
LOCAL: REMOTA - https://meet.google.com/rud-rvhf-jvj
TITLE:

CHIKUNGUNYA IN RIO GRANDE DO NORTE: EPIDEMIOLOGICAL AND CLINICAL ASPECTS

KEY WORDS:

Chikungunya Fever; Epidemic; Brazil.

PAGES: 78
BIG AREA: Ciências Biológicas
AREA: Imunologia
SUMMARY:

Originating in Africa and first isolated in 1952, the Chikungunya virus (CHIKV) belongs to the genus Alphavirus and has mosquitoes of the genus Aedes as its main vectors. Chikungunya vírus infection is an acute and self-limited febrile syndrome caused by this arbovirus and affects people of all age groups, causing different symptoms that can last a few days or even years, which represents a serious problem for public health. This study aimed to describe the epidemiological, immunological and clinical aspects of chikungunya fever from the epidemic that occurred in 2016 in the state of Rio Grande do Norte. A total of 284 suspected cases of CHIKV infection submitted to the qRT-PCR technique were analyzed, from which 125 cases were positive (44.4%). The highest number of positive cases occurred in the first quarter of the year, being March the most representative month, reaching 48 positive cases. The city of Natal up the highest number sum of confirmed cases, accounting for 87 among the positive samples. Women represented the highest (52%) frequency, of which 9.2% of them were pregnant. Positive neonates represented 5.6%.The mean age of positive cases was 34 years and the age group above 61 years was one of the most affected by CHIKV. Most positive cases were detected from serum samples (41.2%). Based on the time of symptoms onset and viremia, it was found that the highest viral load occurred in the acute phase of the infection. CHIKV was detected in ten individuals 23 days after the onset of symptoms. CHIKV-negative samples were also tested for DENV and ZIKV viruses using RT-PCR and qRT-PCR techniques, respectively. In addition, to investigate the possibility of flavivirus infection, a total of 120 suspected cases of CHIKV qRT-PCR negative were further tested for anti-Flavivirus and anti-Chikugunya IgM using the ELISA method of those, 57 sera (47.5%) were anti-Chikungunya IgM detectable. Among the anti-Chikungunya IgM negative sera, 21 (21.7%) were positive for anti-Flavivirus IgM and 54 presented IgM to both Chikungunya and Flavivirus simultaneously. With regards to the clinical features of CHIKV cases, it was noticed that symptoms such as fever, arthralgia and conjunctivitis were the most common of which, the first symptom represented 91% of the cases. Skin blisters were a sign found in all seven newborns studied and positive for CHIKV. However, although four adults also presented that sign, only one was positive. Myalgia, arthralgia, fever, and back pain were the most reported symptoms on the first day of diseases, but fever and arthralgia remained more constant after the fifth day. These results aim to contribute and build up knowledge on the clinical and epidemiological characteristics of CHIKV transmission and assist the clinical diagnosis of the infection.

COMMITTEE MEMBERS:
Externo à Instituição - MARCELO SOUZA DE ANDRADE - UFMA
Externa à Instituição - FERNANDA DE BRUYCKER NOGUEIRA - Fiocruz - RJ
Externa ao Programa - 1714243 - DANIELLA REGINA ARANTES MARTINS SALHA - nullExterno ao Programa - 348473 - JOSE VERISSIMO FERNANDES - nullPresidente - 350647 - SELMA MARIA BEZERRA JERONIMO