Banca de DEFESA: WOGENES NUNES DE OLIVEIRA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : WOGENES NUNES DE OLIVEIRA
DATE: 25/11/2022
TIME: 09:30
LOCAL: REMOTA - https://meet.google.com/qnx-cqjc-ysg
TITLE:

LINSEED OIL MICROEMULSION CONTAINING XANTHAN GUN: DEVELOPMENT AND IN VITRO WOUND HEALING POTENTIAL EVALUATION

KEY WORDS:

Linseed oil; Microemulsion; Xanthan Gum; Topical Delivery; Wound Healing.

PAGES: 101
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

In light of the linseed oil wound healing activity attributed to its chemical composition and the disadvantages related to its in natura use, the aim of this work was to develop and characterize a microemulsion containing xanthan gum to topical delivery of linseed oil. Then, the microemulsion was produced by sonication - ultrassom cycles and characterized by mean droplet size, polidispersivity index (PdI), pH and conductivity. The xanthan gum was added for evaluation of viscosity, rheological behavior and spreadability. In addition, the in vitro wound healing activity was assessed by crystal violet and scratch assay. Then, the linseed oil microemulsion (LOMe) showed mean droplet size distribution of 25.2 ± 3.8, PdI of 0.20 ± 0.02, pH 5.29 ± 0.08 and conductivity 296 ± 2.1 μS/cm, which remained stable over 30 days at 25 ± 2 °C. In addition, was verified maximum spreadability of 2129 ± 277.13 mm² and viscosity of 157 ± 9.51 cP for LOMe containing xanthan gum, which presented a pseudoplastic rheological behavior. The data regarding in vitro assays showed that both in natura linseed oil and developed microemulsion promoted 3T3 cell proliferation and migration, highlighting their wound healing effect. Therefore, the linseed oil microemulsion containing xanthan gum stands out as a promising system to topical delivery of linseed oil as a wound healing agent.

COMMITTEE MEMBERS:
Interno - 346138 - ALDO DA CUNHA MEDEIROS
Externo à Instituição - ELENARA TEIXEIRA LEMOS SENA - UFSC
Presidente - 1178187 - ERYVALDO SOCRATES TABOSA DO EGITO
Externa à Instituição - Nereide Stela Santos Magalhães - UFPE
Interno - 2329140 - RAIMUNDO FERNANDES DE ARAUJO JUNIOR