Banca de QUALIFICAÇÃO: BARTIRA MIRIDAN XAVIER CORTEZ RODRIGUES REBOUCAS FEIJO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : BARTIRA MIRIDAN XAVIER CORTEZ RODRIGUES REBOUCAS FEIJO
DATE: 25/11/2022
TIME: 14:30
LOCAL: REMOTA - https://meet.google.com/mtt-eqhd-ooz
TITLE:

CORONARY ARTERIAL CALCIFICATION IN PATIENTES WITH GENERALIZED LIPODYSTROPHY : A CASE SERIES

KEY WORDS:

Cardiovascular Risk; Berardinelli Seip Congenital Lypodistrophy; Coronary Arteriosclerosis; Calcium Score; XRay Computed Tomography.

PAGES: 22
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Congenital generalized lipodystrophy (CGL) is a rare disease characterized by an absence of subcutaneous adipose tissue, hypoleptinemia, and marked insulin resistance. Although previous articles have described cardiovascular events in CGL patients, few studies have examined the prevalence of atherosclerotic disease. The coronary calcium score (CCS) is a validated method to determine subclinical atherosclerotic disease and has been increasingly applied for this purpose. We used CCS to evaluate the presence of subclinical atherosclerotic disease in CGL patients. Methods: In this descriptive study, we prospectively evaluated 19 CGL patients without a history of previous cardiovascular events. Following standardized protocol to evaluate the CCS, computed tomography was carried out, and the presence of any coronary artery calcification (CAC) was considered indicative of coronary heart disease. Results: Mean patient age was 21.1±13.1 years, with eight children (42.1%; aged 8.4±2.1 years) and 11 adults (57.9%; aged 30.4±9.0 years); Mean BMI was 19.1±3.5 kg/m2 , and 11 patients (57.8%) were women. Five patients (26.3%) had CAC; they were older than patients with no CAC (33.6 11.1 vs. 16.6 10.8 years old, p=0.02). No relationship was found between the presence of CAC and the use of metreleptin. the altered FIB-4 score was a significant predictor of CAC, even after adjusting for age, blood glucose, and, and diabetes increased the risk of altered CCS in more than two times (RR 2.25; CI 95 1.08 - 4.67). Conclusions: CAC is frequent in CGL patients and can indicate a high cardiovascular risk in this population.

COMMITTEE MEMBERS:
Externo ao Programa - 2442045 - ANDRE GUSTAVO PIRES DE SOUSA - nullPresidente - 1451614 - JOSIVAN GOMES DE LIMA
Externa ao Programa - 8347651 - MARIA DE FATIMA PAIVA BARACHO - null