Banca de DEFESA: EDUARDA PONTES DOS SANTOS ARAUJO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : EDUARDA PONTES DOS SANTOS ARAUJO
DATE: 07/11/2023
TIME: 09:30
LOCAL: REMOTA - https://meet.google.com/kmo-hgcg-tof
TITLE:

STUDY OF ASSOCIATION OF VDR AND CYP2R1 GENES POLYMORPHISM WITH VITAMIN D STATUS IN OVERWEIGHT ADOLESCENTS

KEY WORDS:

Vitamin D; Genetic polymorphisms; VDR; CYP2R1

PAGES: 23
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Associations between vitamin D deficiency and metabolic syndrome (MS) have been reported; however, the underlying biological mechanisms remain controversial. The aim of this study was to investigate the associations of CYP2R1 and VDR variants with MS and MS components in non-diabetic Brazilian adolescents. This cross-sectional study included 174 adolescents who were classified as overweight/obesity. Three CYP2R1 variants and four VDR variants were identified by allelic discrimination. The CYP2R1 polymorphisms, rs12794714 (GG genotype) (odds ratio [OR] = 3.54, 95% confidence interval [CI] = 1.24-10.14, p = 0.023) and rs10741657 (recessive model – GG genotype) (OR = 3.90, 95%CI = 1.18-12.92, p = 0.026), were significantly associated with an increased risk of MS and hyperglycemia, respectively. The AG + GG genotype (dominant model) of the rs2060793 CYP2R1 polymorphism was associated with hyperglycemia protection (OR = 0.28, 95%CI = 0.08-0.92, p = 0.037). Furthermore, the CC genotype (recessive model) of the rs7975232 VDR polymorphism was significantly associated with a risk of hypertension (OR = 5.91, 95%CI = 1.91-18.32, p = 0.002). In conclusion, the CYP2R1 rs12794714 polymorphism could be considered a possible new molecular marker for predicting the risk of MS; CYP2R1 rs10741657 polymorphism and  VDR rs7975232 polymorphism  are associatd with an increased risk of diabetes and hypertension in adolescents with overweight/obesity.

COMMITTEE MEMBERS:
Interna - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externa ao Programa - 3218336 - BRUNA ZAVARIZE REIS - nullExterna à Instituição - CRISTIANE COMINETTI - UFG
Externa à Instituição - DIRCE MARIA LOBO MARCHIONI - USP
Externo ao Programa - 1451614 - JOSIVAN GOMES DE LIMA - null