Banca de QUALIFICAÇÃO: SÉPHORA LOUYSE SILVA DE AQUINO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : SÉPHORA LOUYSE SILVA DE AQUINO
DATE: 04/11/2023
TIME: 09:00
LOCAL: REMOTA - https://meet.google.com/dwd-guaw-yzx
TITLE:

VITAMIN D SUPPLEMENTATION IN INDIVIDUALS WITH METABOLIC SYNDROME

KEY WORDS:

metabolic syndrome; 25(OH)D; vitamin D supplementation.

PAGES: 71
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Metabolic syndrome (MetS) is a set of metabolic disorders, including insulin resistance, atherogenic dyslipidemia, central obesity and hypertension. Vitamin D deficiency has been observed in individuals with MetS. The thesis presented was composed of two studies, the first, clinical trial no controlled (study 1) and the second, a systematic review (study 2). These studies aims to evaluate the effects of vitamin D supplementation in individuals with MetS. Study 1 was carried out with 23 individuals diagnosed with MetS, and 25(OH)D ≤ 20 ng/mL. Vitamin D supplementation was performed in two phases. In the first, 50,000IU/week was administered for eight weeks and in the second, 7,000IU/week for 12 weeks. The systematic review (study 2) was conducted with randomized clinical trials (RCTs), following the criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the synthesis without metanalysis (SWiM) guidelines. The searches were performed in the EMBASE, MEDLINE, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrial.gov, and Google Scholar databases, considering the period from 1998 to May 2022 and using MeSH terms. The risk of bias assessment was performed using the Cochrane Risk of Bias 2.0 (RoB 2) tool. The primary outcome considered was the effect of vitamin D supplementation on the lipid profile (triglycerides and HDL-c) and the secondary outcomes were fasting glucose, blood pressure and waist circumference. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach was applied to assess the certainty of the evidence. In study 1, a significant increase in 25(OH)D (26.42 ng/mL) was observed after eight weeks of intervention; and 14.27 ng/mL after 20 weeks of intervention. The intervention lasting 20 weeks resulted in an increment of 12.1 ng/mL of 25(OH)D, however, it was not responsive in the MetS components. Seven RCTs were included in the systematic review (study 2) and all reported a significant increase in 25(OH)D in the intervention groups. However, only two RCTs reported a significant decrease in triglycerides and waist circumference and there is low and very low certainty of evidence for these results. The findings of the two studies emphasize the importance of vitamin D supplementation in individuals with MetS for the correction of vitamin D status, but are inconclusive regarding the benefit in the components of MetS.

COMMITTEE MEMBERS:
Interna - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Externa ao Programa - 2495705 - GRASIELA PIUVEZAM - nullInterna - ***.476.444-** - LUCIA DE FATIMA CAMPOS PEDROSA - UFRN