Banca de QUALIFICAÇÃO: RAFAELLA RÊGO MAIA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RAFAELLA RÊGO MAIA
DATE: 27/09/2022
TIME: 09:00
LOCAL: REMOTA - https://meet.google.com/pwc-nxtx-nap
TITLE:

COMPARATIVE EFFECTS OF FRACTIONAL RADIOFREQUENCY AND MICRONEEDLING ON THE GENITALIA OF POSTMENOPAUSAL WOMEN: HISTOLOGICAL AND CLINICAL CHANGES

KEY WORDS:

Menopause; Flaccidity; Radiofrequency; Microneedling

PAGES: 18
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Background

OBJECTIVES: We aimed to evaluate clinical and histological changes induced by Fractional Radiofrequency (FRF) and microneedling in vulvar tissue.

METHODS: Thirty postmenopausal women were randomly divided into G1 (FRF) and G2 (microneedling) groups. Sub-ablative FRF was executed using disposable fractionated electrodes with an intensity of 8 mJ. Microneedling was performed using a derma roller system. We evaluated before and after treatment using the Vaginal Laxity Questionnaire [VLQ], EuroQol five-dimensional [EQ-5D] questionnaire, and the Blatt and Kupperman menopausal index [BKMI]. Additionally, we performed biopsies of the labia majora for histological analysis pre- and post-treatment. Data were expressed as mean (± standard deviation). A paired t-test was used for intra-group comparison (pre- and post-treatment), with an independent t-test used to compare intergroup data (both pre- and post-treatment).

RESULTS: In the G1 group, the VLQ values showed differences compared to the pre-treatment values with the data obtained 60 days after the beginning of the sessions (p=0.01). Similarly, the data changes of the G2 group proved to be significant (p=0.001) across the same time interval. In comparing the groups, VLQ values were not different (p>0.05). Regarding histological analysis, FRF demonstrated improvement concerning the number of fibroblasts, blood vessels, and fatty degeneration (p<0.05) compared to the control. Additionally, FRF and microneedling samples showed higher type III collagen and vimentin expression in the immunohistochemical analysis (p<0.05).

CONCLUSIONS: The therapies were found to be effective in treating the flaccidity of the female external genitalia. Additionally, histological changes were observed after interventions suggesting collagen remodelling.

COMMITTEE MEMBERS:
Interna - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Externa ao Programa - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS - UFRNExterna ao Programa - 2786809 - MARIA THEREZA ALBUQUERQUE BARBOSA CABRAL MICUSSI - UFRN