Banca de QUALIFICAÇÃO: MARINA SAMPAIO DE MENEZES CRUZ

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARINA SAMPAIO DE MENEZES CRUZ
DATE: 03/05/2021
TIME: 08:00
LOCAL: DEFESA REMOTA - meet.google.com/zaf-zszb-ose
TITLE:

KCNE1 expression as indicator of left ventricular dysfunction post-acute myocardial infarction

KEY WORDS:

Acute myocardial infarction, Heart Failure, mRNA expression, biomarker

PAGES: 16
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Background: Heart failure (HF) is a frequent cause of morbidity and mortality, and acute myocardial infarction (AMI) remains the most common primary cause of HF, leading to left ventricular (LV) dysfunction. Early prediction of LV dysfunction is essential to improve poor outcomes. Previously, our research group identify 13 mRNAs involved in the first 48 hours of AMI and also involved with coronary artery disease. This study aimed to evaluate these genes’ expression after AMI, in patients with ischemic HF, compared to those who had no cardiac complications after AMI.

Methods and Results: Patients who had suffer previous AMI were assorted in two groups: LV dysfunction [LV ejection fraction (LVEF) £ 40%] and those with normal LV function (LVEF > 45%). Expression of ALOX15, AREG, BCL2A1, BCL2L1, CA1, COX7B, ECHDC3, IL18R1, IRS2, KCNE1, MMP9, MYL4 and TREML4 were assessed by RT-qPCR. Only KCNE1 expression was decrease in LVEF £ 40% group (p = 0.007). Positive correlation was found between KCNE1 and ejection fraction (r = 0.557; p = 0.001). There was a risk of 12.25-fold (95%CI: 1.33 – 113.06; p = 0.027) of LV disfunction for patients with lower KCNE1 expression. KCNE1 expression showed high AUROC (AUROC: 0.811, 95%CI: 0.642-0.979, p = 0.007), indicating KCNE1 expression as a good predictor in cardiac outcomes.

Conclusions: This study suggests that KCNE1 expression could be related with a LVEF levels and, therefore, with the establishment of post-AMI HF. Also, KCNE1 expression seems to be a potential predictor of the LVEF.

BANKING MEMBERS:
Presidente - 2087759 - ANDRE DUCATI LUCHESSI
Interna - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externa ao Programa - 2495713 - ROSIANE VIANA ZUZA DINIZ