Banca de DEFESA: KARINA MARQUES VERMEULEN

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : KARINA MARQUES VERMEULEN
DATA : 23/05/2019
HORA: 14:30
LOCAL: Departamento de Nutrição
TÍTULO:

Relationship between zinc and functional parameters in healthy children and in boys with Duchenne Muscular Dystrophy

PALAVRAS-CHAVES:

Zinc, Body Composition, Cellular Membrane, Children, Duchenne Muscular Dystrophy.

PÁGINAS: 16
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

Childhood is a period of rapid growth and development. Zinc is a micronutrient that exerts important structural functions and acts in the maintenance of cellular functionality. Functional indicators of nutritional status for the evaluation of children include anthropometric indices and measures of body composition assessment. The parameters derived from bioelectrical impedance, phase angle (AP) and bioelectrical impedance vector analysis (BIVA) have been associated to the integrity of the cell membrane and cellular body mass. In addition, BIVA has been shown to be useful in evaluating other clinical conditions, where traditional assessment methods are not reliable. Duchenne Muscular Dystrophy (DMD) is a disease characterized by progressive loss of functional muscle mass followed by changes in body composition. To date, there are no studies evaluating the influence of different doses of oral zinc supplementation on cell integrity and functionality, using AF and BIVA as evaluation methods. The aim of this dissertation was to analyze the influence of zinc on functional and serum zinc parameters in healthy children and in children with DMD. For this to happen, two studies were conducted. The first one evaluated changes in the functional parameters of 71 healthy children supplemented orally with zinc at different concentrations (Study 1) and the second described the functional parameters in 41 boys with DMD (Study 2). As a result, we have seen that for healthy children supplementation with 10 mg Zn / day promoted changes in the integrity of the cell membrane associated with increased cell mass. We also found that, in comparison with the reference population, boys with DMD had lower levels of body cell mass. Understanding that zinc plays an important role in the cell membrane, the results of this dissertation will serve as the basis for a future study evaluating oral zinc supplementation in other populations.

MEMBROS DA BANCA:
Presidente - 1216686 - JOSE BRANDAO NETO
Externo ao Programa - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Externa à Instituição - MARIA JOSÉ DE CARVALHO COSTA