Banca de DEFESA: SUSIANE DE SANTANA MOREIRA OLIVEIRA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : SUSIANE DE SANTANA MOREIRA OLIVEIRA DA SILVA
DATA : 19/11/2018
HORA: 09:30
LOCAL: Sala de Reuniões do CONSEC
TÍTULO:

Buccal Bullfrog (Rana Catesbeiana Shaw) Oil Emulsion: A Mucoadhesive System Intended For Treatment Of Oral Candidiasis

PALAVRAS-CHAVES:

Bullfrog oil, buccal emulsion, mucoadhesive properties, antifungal activity, biocompatibility

PÁGINAS: 33
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Oral candidiasis (OC) is an infectious disease caused by microorganisms of the genus Candida, leading to lesions in the buccal cavity. Its treatment consists on the administration of topical or systemic antifungal agents, which may compromise the patient compliance due to its side effects, highlighting the need for alternative treatments able to remove this infection and avoid the side effects of the current treatment. In this scenario, the bullfrog oil, an animal oil composed by a pool of saturated and unsaturated fatty acids, is introduced as a potential antifungal raw material. Thus, the aim of this work was to produce a mucoadhesive emulsified system able to deliver the bullfrog oil in the buccal cavity to treat the OC. The emulsion was produced and characterized by visual inspection, droplet size, polydispersivity index (PdI) and zeta potential and its stability was assayed over 60 days. In addition, its mucoadhesive ability was evaluated using an in vitro mucin model. The antifungal activity by broth microdilution assay and biocompatibility against human erythrocytes were also performed. The emulsion showed droplet size of 320.79 ± 35.60 nm, PdI of 0.49 ± 0.08 and zeta potential of -38.53 ± 6.23 mV, which showed no significant changes over 60 days. The mucoadhesive properties of the system were improved by the use of pharmaceutical excipients and the antifungal activity showed that the bullfrog oil and the emulsion were able to inhibit the growth of different Candida species. Furthermore, the emulsion showed no significant hemolytic effect. Overall, the system showed suitable physicochemical characteristics and biocompatibility, with substantial in vitro antifungal activity, suggesting that this emulsion can be further investigated for OC treatment.

MEMBROS DA BANCA:
Presidente - 1178187 - ERYVALDO SOCRATES TABOSA DO EGITO
Externo ao Programa - 1052612 - RODRIGO DOS SANTOS DINIZ
Externo à Instituição - TOSHIYUKI NAGASHIMA JUNIOR - UFCG