Banca de DEFESA: ALDAIR DE SOUSA PAIVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : ALDAIR DE SOUSA PAIVA
DATA : 18/05/2018
HORA: 09:00
LOCAL: Sala de Reuniões do CONSEC
TÍTULO:

CLINICAL RELEVANCE OF FLOW CYTOMETRY IMMUNOPENOTYPING AND
HEMATOLOGICAL FIND IN DIAGNOSIS AND CLASSIFICATION OF CHRONIC
LYMPHOPROLIFERATIVE DISEASES.

PALAVRAS-CHAVES:

Flow cytometry; Immunophenotyping; Hematological parameters; Chronic
lymphoproliferative diseases.

PÁGINAS: 92
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Background: Chronic lymphoproliferative disorders (CLPD) constitute a group of lymphatic
malignancies that are characterized by proliferation of neoplastic mature lymphocytes, and
may be sourced B, T and natural killer cells (NK). Flow cytometric (FC) immunophenotyping is
a routine practice in the differential diagnosis of these tumors, contributing to greater accuracy
and new therapeutic perspectives. Methods: Patients (n= 500) with CLPD were investigated
by FC. In addition, we also gathered patient information such as age, sex and hematologic
data. Results: The results showed that 408 (81,6%) of cases were B-cell and 92 (18,4%)
were T lymphocytes and NK cells. B-cells CLPD distribution was: 265 B-cell chronic
lymphocytic leukemia, 17 B-cell prolymphocytic leukemia, 11 Hairy cell leukemia, 3 Follicular
lymphoma in leukemic phase, 3 Splenic lymphoma with villous lymphocytes, 12 mantle cell
lymphoma, one Waldenstrong macroglobulinemia, 47 multiple myeloma, 12 plasma cell
leukemia, 9 Burkitt lymphoma and 37 B-cell CLPD with non-specific immunoclassification. The
T/NK CLPD classification were: 11 Large granular lymphocyte leukemia (10 of T lymphocytes
and one NK cells), 47 T-cell prolymphocytic leukemia, 10 Adult T-cell leukemia lymphoma, 8
Sezary syndrome and 24 T-cell peripheral lymphoma. Conclusion: The data suggest that
immunophenotyping is an important method in diagnosis, monitoring and prognosis when
determining the pathological mechanisms of CLPD evolution.

MEMBROS DA BANCA:
Interno - 346138 - ALDO DA CUNHA MEDEIROS
Externo à Instituição - AMALIA CINTHIA MENESES DO REGO - UnP
Externo à Instituição - CARLOS ROBERTO ALVES - Fiocruz - RJ
Presidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR
Externo ao Programa - 346993 - MARIA ZELIA FERNANDES