Banca de DEFESA: HÉVILA DE FIGUEIREDO PIRES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : HÉVILA DE FIGUEIREDO PIRES
DATE: 23/09/2022
TIME: 09:00
LOCAL: DEPARTAMENTO DE ODONTOLOGIA - AUDITÓRIO
TITLE:

AMELOBLASTOMA RECURRENCE: PROGNOSIS STUDY

KEY WORDS:

Ameloblastoma; Recurrence; Prognosis; Immunohistochemistry; DNA damage. DNA Mismatch Repair.

PAGES: 75
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Introduction: Ameloblastoma (AMB) is a benign odontogenic neoplasm that has high rates of postoperative recurrence. Several studies show the relationship between clinical-pathological characteristics and treatment modalities in AMB recurrence. The molecular mechanisms involved in the etiopathogenesis of this tumor are poorly understood, and although alterations in the Mismatch System (MMR) favor the development of different human neoplasms, their importance in the development of ameloblastoma remains poorly understood. Objective: To identify the prognostic factors associated with ameloblastoma recurrence, as well as to investigate the role of the immunoexpression of hMLH1, hMSH2 and KI-67 proteins in the recurrence of these odontogenic tumors. Methodology: This was a descriptive, cross-sectional and retrospective study, with a sample consisting of 22 cases of recurrent ameloblastomas and 22 non-recurring cases. The immunohistochemical analysis was performed quantitatively, considering the cellular (nuclear) location of the proteins studied. McNemar's test was used to compare the variables between primary and recurrent ameloblastoma lesions. Recurrence-free survival was analyzed using the Kaplan-Meier method and survival functions were compared according to variables using the log-rank test. Results: The total sample was mostly female (n=24; 54.5%), with a mean age of involvement of 39.1 ± 19.8 years, and 45.5% (n=20) were caucasian. The posterior mandible region was the most frequent in the relapsed group (n=18, 81.8%) and also for the cases that did not present relapses (n=16, 72.8%). The recurrence-free time was 50.0 (34.5 – 63.6) months. Factors significantly associated with the recurrence of AMBs were: expansion of cortical bone (p=0.0089), presence of bone reconstruction (p=0.018), conservative treatment (p=0.021), loss of hMSH2 immunoexpression (p=0.006) and hMLH1 (p=0.038) and strong immunoexpression of KI-67 (p=0.029). Conclusion: Based on the findings of this research, it is concluded that radiographic appearance, treatment modality and immunoexpression of proteins from the Mismatch System and KI-67 are the most significant prognostic factors for the recurrence of AMBs.

COMMITTEE MEMBERS:
Presidente - 350485 - HEBEL CAVALCANTI GALVAO
Externo à Instituição - MANUEL ANTONIO GORDON NUNEZ - UEPB
Interna - 350484 - ROSEANA DE ALMEIDA FREITAS