Banca de DEFESA: TATIANA BERNARDO FARIAS PEREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : TATIANA BERNARDO FARIAS PEREIRA
DATE: 30/08/2022
TIME: 14:30
LOCAL: DEPARTAMENTO DE ODONTOLOGIA - SALA DE AULAS III
TITLE:

RISK FACTORS ASSOCIATED TO THE DEVELOPMENT OF ORAL alterations IN PATIENTS UNDER HEMATOPOIETIC STEM CELL TRANSPLANTATION: A COHORT STUDY

KEY WORDS:

Hematologic neoplasms. Hematopoietic stem cell transplantation. Bone marrow. Oral alterations.

PAGES: 80
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Hematopoietic stem cell transplantation can cause adverse effects on the oral environment that can affect the patient's response to treatment and the prognosis. Thereby, this study aimed to identify the most prevalent oral alterations during the period of hospitalization for the performance of HSCT, to analyze the development time of these alterations in this period, as well as the factors associated with the development of these alterations. It was an observational longitudinal, cohort study carried out in patients that was assisted by the bone marrow transplant sector in a main hospital in Rio Grande do Norte between December 2021 and June 2022. Data about oral physical examination, diagnosis of hematological disorder, type of transplant, comorbidities, chemotherapy protocols and local risk factors of patients obtained during the HSCT period were submitted to the Kaplan-Meyer test, parametric logrank test and univariate COX regression to estimate the time of oral changes' onset of and association of risk factors. The statistical significance adopted was 5%. 57.7% of the 30 selected patients were male, median age of 35 years, where 93.3% developed some oral alteration and 53.3% started treatment with some risk factor. The most frequent neoplasms were leukemias (myeloid and lymphoid) and multiple myeloma (23.3% each). FluBuMel was the most used conditioning protocol (40%). The most frequent oral alteration was buccal mucosa edema (83.3%) followed by oral mucositis (80%; grade 1 - 54.2%). The follow-up time was on average 23 days and it was found that on the 5th day of hospitalization the probability of the patient being free of alterations is 93.3%, with this rate decreasing over time, reaching 6.7% in the 28th day. The Mel200 protocol is associated with earlier development of alterations (p=0.02), as well as autologous transplantation (p=0.004). The results suggest that the type of transplant and the chemotherapy conditioning protocol affects the time of onset of oral alterations and additionally reinforce that the low severity of the oral alterations is directly related with the presence of a dentist in the multidisciplinary team.

COMMITTEE MEMBERS:
Interna - 2085732 - ANA RAFAELA LUZ DE AQUINO MARTINS
Presidente - 2492713 - ERICKA JANINE DANTAS DA SILVEIRA
Externa à Instituição - JAMILE MARINHO BEZERRA DE OLIVEIRA MOURA - UERN