Banca de DEFESA: CAIO RODRIGUES MAIA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : CAIO RODRIGUES MAIA
DATE: 11/08/2022
TIME: 14:30
LOCAL: DEPARTAMENTO DE ODONTOLOGIA-AUDITORIO
TITLE:

Use of Cell Morphometry as a Biomarker in the Neoplastic Microenvironment and its Relationship with IL-4 Immunoexpression

KEY WORDS:

Nuclear Morphometry; Cell Morphology; Oral Epidermoid Carcinoma; IL-4; Immunohistochemistry

PAGES: 72
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Keratinized stratified squamous epithelium is a type of lining epithelial tissue that is present in the skin and mucous membranes that are predominantly made up of keratinocytes. These cell types produce keratin and have a polyhedral morphology with ovoid nuclei, but they can modify their phenotype according to the degree of differentiation in the layers of the epithelial component. The normal morphology of keratinocytes may vary according to the physiological events that occur, such as changes in the regularity and size of the nucleus at different stages of apoptotic, mitotic or replicative activity. However, cellular alterations may be present in some malignant neoplasms, such as squamous cell carcinoma and basal cell carcinoma, modifying the original morphology of keratinocytes as a result of an eventual alteration of the malignant phenotype of these cells. Interleukin-4 (IL-4) is a cytokine secreted by several types of cells, being involved in the development and differentiation of Th2 cells, acting in the anti-inflammatory response, its expression also seems to be related to the development of some neoplasms, including oral cancer. The objective of the present research will be to perform a cellular morphometric analysis (nuclear and cytoplasmic compartments), identification of nuclear irregularities of malignant keratinocytes and compare with the immunohistochemical expression of IL-4 in cases of Epidermoid Carcinoma of the Lower Lip (n:30) and Oral Tongue (n:30) using biotechnology tools for this purpose, contributing to the understanding of the biological behavior of these cell types in malignant neoplasms.

COMMITTEE MEMBERS:
Interno - 2220417 - CARLOS AUGUSTO GALVAO BARBOZA
Externa à Instituição - KEILA MARTHA AMORIM BARROSO - UFPB
Presidente - 2859541 - PEDRO PAULO DE ANDRADE SANTOS