Banca de QUALIFICAÇÃO: LARISSA SANTOS AMARAL ROLIM

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : LARISSA SANTOS AMARAL ROLIM
DATE: 14/07/2022
TIME: 09:00
LOCAL: PLATAFORMA REMOTA
TITLE:

Behavior of Adenoid Cystic Carcinoma Under Chemotherapy and Analysis of Epithelial-Mesenchymal Transition Markers

KEY WORDS:

Adenoid Cystic Carcinoma, Twist-Related Protein 1, Snail Family Transcription Factors, Epithelial-Mesenchymal Transition, Oral Pathology

PAGES: 56
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Salivary gland tumors consist of benign and malignant neoplasms with remarkable histopathological complexity and diverse patterns of clinical behavior, which generate difficulties in the diagnosis and treatment of these pathological entities. In the context of these tumors, Adenoid Cystic Carcinoma (ACC) corresponds to the second most common malignant tumor, according to epidemiological studies. The ACC is also characterized by persistent and invasive growth, with a high tendency to local recurrences and distant metastases, and it has been described as one of the most aggressive and unpredictable tumors of the head and neck region. It is believed that the mechanism responsible for tumor progression is based on the collective or individual cell invasion, kwon as Epithelial-Mesenchymal Transition (EMT), where occur a decrease in the expression of epithelial biomarkers, such as E-cadherin, and increased expression of mesenchymal biomarkers, such as Twist, Snail and Vimentin. Cisplatin does not yet have clear benefits for patients' survival rates, since patients with ACC are relatively insensitive to chemotherapy because of the natural indolent course of the disease, making the surgical approach the most viable therapy most of the time. In this manner, it is essential the discovery of specific biomarkers for potential therapies directed to genes involved in the invasion and resistance to cisplatin process, aiming at improving the prognosis and increasing the survival rate of patients with ACC. Thus, the present project aims to conduct a research on immunoexpression in ACC specimens and the influence of EMT transcription factors on migratory and proliferative potential in an ACC cell line, through exposure to cisplatin. The data obtained will be entered in spreadsheets in Excel software and later exported to the Statistical Package for the Social Sciences program. For all statistical tests, a significance level of 5% (p <0.05) will be established.

COMMITTEE MEMBERS:
Presidente - 344668 - LEAO PEREIRA PINTO
Interna - ***.887.244-** - LELIA BATISTA DE SOUZA - UFRN
Interna - 350484 - ROSEANA DE ALMEIDA FREITAS