Banca de QUALIFICAÇÃO: RANI IANI COSTA GONÇALO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : RANI IANI COSTA GONÇALO
DATE: 21/07/2022
TIME: 09:00
LOCAL: PLATAFORMA REMOTA
TITLE:

THE INFLUENCE OF YES-ASSOCIATED PROTEIN (YAP) ON CELL PROLIFERATION AND APOPTOSIS IN BENIGN EPITHELIAL ODONTOGENIC LESIONS

KEY WORDS:

Yes-associated protein; Cell proliferation; Apoptosis; Odontogenic cysts; Odontogenic tumors; Immunohistochemistry.

PAGES: 80
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Several conditions can affect the maxillomandibular complex, among which odontogenic cysts and tumors stand out. These lesions develop from the entrapment of tissue remnants of odontogenesis in soft tissues or jaw bones. According to their cellular origin, odontogenic cysts are classified as inflammatory or developmental; odontogenic tumors are classified as epithelial, mixed, or mesenchymal. Some lesions, such as dentigerous cyst (DC), present an indolent behavior, while others, such as odontogenic keratocyst (OKC) and ameloblastoma (AMB), are characterized by aggressive behavior and high recurrence rates. As they are among the most frequent odontogenic lesions, studies have been developed focusing on their pathogenesis, in order to elucidate the molecular mechanisms underlying their development. Therefore, changes in the expression of markers related to the proliferative potential of the odontogenic epithelium, such as Cyclin D1 (CCND1), Ki-67, and Bcl-2, have been shown to directly influence cystic/tumor growth, as well as the biological behavior of odontogenic cysts and tumors. Studies have shown that the overexpression of these markers is related to the aggressiveness inherent to more aggressive lesions, especially CO and ameloblastoma. In turn, the YAP protein (Yes-associated protein) has been highlighted for acting as a transcriptional co-activator/repressor of genes involved in cell proliferation and apoptosis suppression, leading to the activation of pathways associated with neoplastic progression. Thus, studies that aim to associate YAP expression with markers involved in cystic and tumor growth make it possible to understand the interaction of these proteins in the pathogenesis of odontogenic lesions. In this context, the present study aims to analyze the immunohistochemical expression of the YAP protein and correlate it with markers involved in apoptosis and cell proliferation in benign epithelial odontogenic lesions.

COMMITTEE MEMBERS:
Externa à Instituição - DENISE HELEN IMACULADA PEREIRA DE OLIVEIRA - UFC
Presidente - 1258693 - LELIA MARIA GUEDES QUEIROZ
Externo à Instituição - LEORIK PEREIRA DA SILVA - UFCG