Banca de QUALIFICAÇÃO: DÉBORA FROTA COLARES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : DÉBORA FROTA COLARES
DATE: 30/06/2022
TIME: 09:00
LOCAL: DEPARTAMENTO DE ODONTOLOGIA - SALA DE AULAS DA PATOLOGIA
TITLE:

IMMUNOEXPRESSION OF E-CADHERIN, SNAIL1 AND VIMENTIN PROTEINS IN SALIVARY GLAND NEOPLASMS. 

KEY WORDS:

Salivary glands. Neoplasms. Pleomorphic Adenoma. Adenoid Cystic Carcinoma. Epithelial-Mesenchymal Transition. Immunohistochemistry. E-cadherin. Snail1. Vimentin.

PAGES: 68
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Salivary glands can be susceptible to several kinds of diseases, and, among them, there are neoplasms, which may be benign or malignant. Salivary gland tumors (SGTs) comprise about 2% to 10% of head and neck tumors and are known for their morphologic diversity, even in the same lesion. Some features of malignant neoplasms, as tumor invasion and distant metastasis, are explained by epithelial-mesenchymal transition (EMT), event in which proteins like E-cadherin, Vimentin and Snail1 are directly involved. This study aims to analyze, by means of immunohistochemistry, the expression of some proteins involved in EMT, as well as to relate their expressions to clinical-pathological features of salivary gland pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs) and carcinomas ex-pleomorphic adenomas (CXPAs). It will be a cross-sectional study using the biomarkers already mentioned in PAs, ACCs, and CXPAs. It will be included in this research 50 cases of SGTs, embedded in paraffin, previously diagnosed at Oral Pathology Service of the Dentistry Department of UFRN; it will be selected 20 PAs, 20 ACCs and 10 CXPAs. First, morphological features will be described. Then, for the immunohistochemistry analysis, E-cadherin and Snail1 will be evaluated by the proportion of positive cells and the expression intensity in tumor parenchyma. Finally, vimentin will be evaluated by its proportion and intensity in cytoplasm of stromal cells. Statistical analysis will be made to compare the expression pattern of these biomarkers, as well as to investigate possible associations with clinical-pathological features of these tumors. With this research, it is expected to better understand pathogenesis and tumoral progression of SGTs, enabling better targeting to alternative therapies for these tumors.

BANKING MEMBERS:
Presidente - ***.887.244-** - LELIA BATISTA DE SOUZA - UFRN
Interna - 1298808 - MARCIA CRISTINA DA COSTA MIGUEL
Interna - 350484 - ROSEANA DE ALMEIDA FREITAS