The Wingless (Wnt) / β-catenin signaling pathway is essential for the early activation of odontogenesis and the development of odontogenic tumors, additionally this pathway is responsible for the expression of high molecular weight cytokeratins, such as CK14 and CK19. TGF-β and BMPs have been associated with reactionary and repair dentinogenesis processes. This growth factor is released by odontoblasts and fibroblasts and is stored inside the dentinal tubules. Tooth development depends on a series of reciprocal signaling interactions between the oral epithelium (EO) and neural crest-derived ectomesenchyma, the WNT pathway with TGF-β and BMP4 has been implicated in the formation of supernumerary teeth during odontogenesis. Meanwhile, Shh signaling can regulate cell proliferation in the dental mesenchyme, thus controlling dental morphogenesis. Therefore, the objective of our work will be to investigate the role of these pathways in odontogenesis and in the formation of odontomas and benign mixed odontogenic tumors. For this, a retrospective and immunohistochemical sectional study was developed containing 23 compound odontomas, 21 complex odontomas, 17 dental germs, 05 ameloblastic fibro-odontomas and 01 ameloblastic fibroma. The results found showed greater immunoexpression of the WNT/ß-catenin pathway in the epithelium of tooth germs (p<0.001) and in ameloblastic fibroma, whereas it was in the ectomesenchyma of odontomas (p<0.001) and ameloblastic fibro-odontomas. WNT/ß-catenin correlated moderately and significantly with CK14 in the epithelium (p<0.001) and ectomesenchyma of all lesions (p=0.018). BMP4 was immunoexpressed, especially in the mesenchyme of complex odontomas (median = 33.7; p<0.001). Shh was more immunoexpressed in the epithelium of tooth germs (p<0.001) and in the ectomesenchyma of complex odontomas (p=0.029). Similarly, TGF-ß showed greater immunoexpression in the epithelium of tooth germs (p<0.001) and in the ectomesenchyma of complex odontomas (p = 0.002). Finally, Odontogenesis exhibits higher concentrations for these proteins in the odontogenic epithelium in the early stages and the change in expression in the ectomesenchyma occurs, mainly, in the histodifferentiation in the bell phase, predisposing to the formation of odontogenic tumors.