Banca de DEFESA: MARIA DO CARMO PESSOA NOGUEIRA SERRÃO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARIA DO CARMO PESSOA NOGUEIRA SERRÃO
DATE: 15/09/2021
TIME: 08:00
LOCAL: PLATAFORMA VIRTUAL
TITLE:

ANALYSIS OF PREDICTORS IN THE DEVELOPMENT OF ORAL CHANGES IN PATIENTS WITH COVID-19.

KEY WORDS:

Coronavirus Infections. Oral Manifestations. Hospital care.

PAGES: 82
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

An outbreak of a new SARS-CoV-2 coronavirus (Severe acute respiratory syndrome coronavirus 2) was identified in Wuhan Province, China in late 2019. SARS-CoV-2, spreads through infected droplets in a person's respiratory system, and causes a respiratory disease called Covid-19 (Coronavirus Disease, 2019). Its clinical behaviour, which in some patients manifests with mild or moderate symptoms, and in others with the development of an important respiratory infection, has instigated many studies. Although risk factors such as age, sex and comorbidities have been highlighted as one of the risk factors that increase morbidity and mortality due to Covid-19, there are still patients without these factors that progress to serious conditions. The oral cavity has been identified as one of the gateways for SARS-CoV-2, and its possible role as an aggravating factor in the infectivity and progression of the viral infection and has been controversial. A retrospective cohort study was carried out with data obtained from 274 medical records of patients with COVID-19 on admission, with seven days and with 14 days to analyse the occurrence of oral alterations and relate them to the severity of the infection. A total of 154 patients with oral alterations and 120 without alterations were found. Of the 154 patients who presented oral changes on admission, 39 achieved remission within 7 days, 54 patients achieved remission within 14 days, and 61 maintained oral changes until the end of the study. Of the 120 patients who did not present oral changes on admission, only 2 developed oral changes within 7 days and these died. The most frequent oral alteration was ulcer in the three collection times (T0: 43.8%, T1: 33.6% and T2: 21.2%). The most prevalent altered biochemical analyses among patients were red blood cells, platelets, leukocytes, bleeding time, TGP, TGO, albumin, creatinine, CRP, urea, d-dimer and leukocyte-lymphocyte ratio. The chi-squared significance found for the occurrence of oral lesions on admission was not being diabetic and not taking medication for the digestive system. For the period of 7 and 14 days, it was observed that the patient was not diabetic, did not take medication for the digestive tract, did not die and was not transferred to the ICU. For the period of 14 days, it was detected that the patient who did not develop an oral lesion had a normal BMI, was not cardiac and was not taking medication for the cardiovascular system. Cox's multivariate analysis revealed that he did not use medication for the digestive system and metabolism (HR: 2.18; 95%CI: 1.13-4.22) and did not present systemic arterial hypertension (HR: 1.78; 95%CI %: 1.13-2.79) are prognostic factors for remission of oral changes in patients with COVID-19.

BANKING MEMBERS:
Presidente - 2644142 - PATRICIA TEIXEIRA DE OLIVEIRA
Interna - 2492713 - ERICKA JANINE DANTAS DA SILVEIRA
Interna - 1258693 - LELIA MARIA GUEDES QUEIROZ
Externo à Instituição - ANTONIO ADILSON SOARES DE LIMA - UFPR
Externa à Instituição - EMELINE DAS NEVES DE ARAUJO LIMA - UFS