Banca de DEFESA: JOYCE MAGALHÃES DE BARROS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JOYCE MAGALHÃES DE BARROS
DATE: 07/07/2021
TIME: 14:30
LOCAL: PLATAFORMA VIRTUAL
TITLE:

IMMUNOEXPRESSION OF ING3 PROTEIN IN ACTINIC CHEILITIS AND LOWER LIP SQUAMOUS CELL CARCINOMAS

KEY WORDS:

Carcinoma, Squamous Cell; Carcinogenesis; Cheilitis; Biomarkers, Tumor.

PAGES: 92
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

The family of inhibitors of growth (ING) corresponds to a group of tumor suppressor genes whose expression is altered or absent in several types of cancer. The products of these genes are mainly related to cellular processes indispensable in carcinogenesis, including cell proliferation, DNA replication and repair. This study evaluated the immunohistochemical expression of ING3 protein in 45 actinic cheilitis (AC) and 48 lower lip squamous cell carcinoma (CCELI) specimens. Protein expression was compared between the two groups of samples, as well as with the clinicopathological parameters of studied lesions, using Fisher's exact tests, Kruskal-Wallis (KW), Mann-Whitney (U) and correlation test of Spearman. A significance level of 5% was adopted for all tests, with values of p ≤ 0.05 being considered significant. No statistically significant associations were found between morphological variables of CCELI and tumor size, lymph node involvement, clinical staging, local recurrence, and lymph node metastasis after treatment (p>0.05). Deaths were significantly more frequent in tumors with a high histopathological risk score (p<0.05). In ACs, significant differences in nuclear-cytoplasmic and restricted to the cytoplasm expression of ING3, with gradation of Kujan et al. (2006) were found (p<0.05). In CCELIs, there was no statistically significant difference when comparing ING3 expressions (nucleocytoplasmic and cytoplasmic restricted) with clinical and morphological parameters (p>0.05). Nucleocytoplasmic ING3 expression was significantly lower in CCELI when compared to AC cases (p<0.05) and cytoplasm-restricted expression was significantly higher in CCELIs (p<0.05). Our results suggest that there is a remarkable decrease in ING3 nuclear expression according to malignant progression, indicating an impaired tumor suppressor function of this protein in AC and CCELI. However, it is believed that, in lip carcinogenesis, ING3 is better characterized as a promising biomarker of malignant transformation, rather than a predictive marker of tumor biological behavior.

BANKING MEMBERS:
Presidente - 344668 - LEAO PEREIRA PINTO
Interna - 346077 - LELIA BATISTA DE SOUZA
Externa à Instituição - ROBERTA BARROSO CAVALCANTE - UNIFOR