Banca de QUALIFICAÇÃO: EMANUELLE LOUYDE FERREIRA DE LIMA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : EMANUELLE LOUYDE FERREIRA DE LIMA
DATE: 10/05/2021
TIME: 16:00
LOCAL: Plataforma google meet
TITLE:

ANTIFUNGAL AND ANTIBIOFILM POTENTIAL OF SPONDIAS MOMBIN L. HYDROETANOLIC EXTRACT FRACTIONS IN FRONT OF CANDIDAL GENDER FUNGI

KEY WORDS:

Anacardiaceae; Phytotherapy; Candidiasis, Oral.

PAGES: 30
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUBÁREA: Clínica Odontológica
SUMMARY:

The antimicrobial action of the hydroethanolic extract of Spondias mombin L. is already known in the literature against several microorganisms, even when placed against fungi of the genus Candida. In addition to antifungal activity, it is essential to investigate the antibiofilm activity of the substances, since these fungi can accumulate and form part of the biofilm present in the oral cavity of individuals causing local and systemic problems, with clinical relevance. Knowing this is that the present study had as main objective to investigate the antifungal and antibiofilm action of the extract of Spondias mombin L. and its fractions, against fungi of the genus candida, of clinical importance. For this, the tests of minimum inhibitory concentration were performed through the use of discs and by the microdilution technique in microplates, minimum inhibitory concentration of adhesion, determination of the fungi death curve and antibiofilm activity of the fractions of phenolic acids, flavonoids and tannin, against the fungi Candida albicans, Candida tropicalis, Candida Krusei and Candida Glabrata, using Nystatin (100,000 IU), in triplicate, as a positive control. It was seen that the antifungal and antibiofilm activity of the fractions analyzed presented satisfactory results, however, inferior to the control group.

BANKING MEMBERS:
Presidente - 1958729 - RUTHINEIA DIOGENES ALVES UCHOA LINS
Interno - 1879551 - FABIO ROBERTO DAMETTO
Externa ao Programa - 3138832 - MARIA REGINA MACEDO COSTA