Banca de DEFESA: MARIA LAURA DE SOUZA LIMA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA LAURA DE SOUZA LIMA
DATE: 24/09/2020
TIME: 14:00
LOCAL: PLATAFORMA REMOTA
TITLE:

VOLUMETRIC AND LINEAR ANALYSIS OF THE MAXILLA IN AN EXPERIMENTAL MODEL OF PERIODONTAL DISEASE: INFLUENCE OF ANGIOTENSIN II AT1 AND AT2 RECEPTORS

KEY WORDS:

Angiotensin II; AT1; AT2; Periodontal disease

PAGES: 53
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUBÁREA: Periodontia
SUMMARY:

Periodontal disease is a multicausal inflammatory process. The Renin-Angiotensin System, whose main modulator is Angiotensin II, is related to electrolyte balance and inflammation. An angiotensin II interacts mainly with two receptors, type 1 (AT1) and type 2 (AT2). This study aimed to perform a volumetric and linear analysis of the maxilla in an experimental model of periodontal disease: influence of angiotensin II receptors AT1 and AT2. Six groups were used, three controls and three experimental, with ten animals each, using three different lines of mice: wild (WT), knockout AT1 and knockout AT2. Periodontal disease was induced through ligation, with 5.0 nylon thread, and after fourteen days the animals were identified by euthanasia. Bone loss was assessed using volumetric and linear analysis using MICRO-CT. In order to analyze whether genetic variations, influence on the phenotypic characteristics of bone tissue, analyzes of the spine and femur of the animals of the three strains used were analyzed. The results obtained from the spine showed a smaller difference in bone density between the WT and AT1 groups (p <0.05). Regarding the number and separation between the trabeculae, there was a difference between the groups WT and AT1 (p <0.01) and WT and AT2 (p <0.05), for both analyzes. There was no significant difference between the knockout strains. The model used was effectively generating bone loss and altered differences between controls and patients (WT and AT1: p <0.001; AT2: p <0.01). In the analysis of the maxilla there were no significant differences between the lines that were submitted to periodontal disease. The knockout of the genes of angiotensin II receptors promoted changes in the bone phenotype of the animals, with these groups having a reduction in bone density and quality. The exclusive presence of the AT1 receptor did not induce greater bone loss, nor did the exclusive presence of the AT2 receptor be shown to be protective, but it seems to be determinant for bone metabolism.

BANKING MEMBERS:
Presidente - 2374605 - AURIGENA ANTUNES DE ARAUJO
Interna - 2085732 - ANA RAFAELA LUZ DE AQUINO MARTINS
Externo à Instituição - RENATA FERREIRA DE CARVALHO LEITÃO - UFC