Banca de DEFESA: NATÁLIA TEIXEIRA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : NATÁLIA TEIXEIRA DA SILVA
DATE: 23/09/2020
TIME: 14:00
LOCAL: Remoto
TITLE:

Evaluation of the anti-inflammatory and antioxidant activity of Lactobacillus rhamnosus EM1107 in an experimental model of periodontitis induced in diabetic rats.

KEY WORDS:

Periodontitis. Diabetes. Probiotic. Inflammation. Biology

PAGES: 70
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUBÁREA: Periodontia
SUMMARY:

Periodontal disease and diabetes share similar chronic immunoinflammatory mechanisms, so probiotic therapy has been suggested as an alternative or complement to non-surgical periodontal therapy. A clinical, in vivo, randomized, blinded and controlled trial was carried out, composed of 70 male Wistar rats, which were randomly divided into five groups with 14 animals each, with the following treatments: (C1) without ligation + distilled water, (C2) ligation + distilled water, (C3) ligation + DM + distilled water, (E1) ligation + EM117, (E2) ligation + DM + EM117. Spectroscopy UV-VIS analysis was used to examine the gingival levels of malonaldehyde (MDA), glutathione (GSH), IL-1β and TNF-α. Treatment with Lactobacillus rhamnosus EM1107 significantly reduced the concentrations of inflammatory cytokines IL-1β and TNF-α (p <0.05), but showed no benefit in modulating oxidative stress when analyzing MDA and GSH levels. This study suggests an anti-inflammatory effect of Lactobacillus rhamnosus EM1107 on ligature-induced periodontitis in diabetic rats.

BANKING MEMBERS:
Presidente - 2085732 - ANA RAFAELA LUZ DE AQUINO MARTINS
Externa ao Programa - 2330188 - GERLANE COELHO BERNARDO GUERRA
Externa à Instituição - SABRINA GARCIA DE AQUINO - UFPB