Banca de QUALIFICAÇÃO: MARIA LAURA DE SOUZA LIMA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA LAURA DE SOUZA LIMA
DATE: 02/07/2020
TIME: 14:00
LOCAL: Plataforma online
TITLE:

Evaluation of the role of at1 and at2 receptors in  periodontal disease experimental induced by ligature

 

KEY WORDS:

Angiotensin II; AT1; AT2; Periodontal disease

PAGES: 48
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUBÁREA: Periodontia
SUMMARY:

Periodontal disease is an inflammatory process that can be influenced by several conditions, including the Renin-Angiotensin System, whose main modulator is Angiotensin II. Angiotensin II interacts mainly with two receptors, type 1 (AT1) and type 2 (AT2). This work aimed to evaluate the effects of the interaction of Angiotensin II with its receptors, AT1 and AT2, and how this interaction could influence the development of the periodontal disease. Six groups were used, three controls and three experimental, with ten animals each, using three different lines of mice: wild type (WT), AT1, and AT2. Periodontal disease was induced through ligation, with nylon thread, and after fourteen days the animals were euthanized. Bone loss and inflammation were analyzed using MICRO-CT, histological and immunohistochemical analysis. In order to analyze whether genetic alterations affect as phenotypic characteristics of bone tissue that are used for analysis of spine and femur columns of animals of the three lines used. The results obtained from the vertebral columns demonstrated that in relation to the bone volume there was a significant difference (p <0.01) between the WT animals and the AT1 strain. Regarding bone density, in the vertebral columns, there was a significant difference p ≤ 0.01 in relation to the wild line and the AT1 animal and in relation to the wild animal and the AT2 line. Regarding the selection of tables, there was a difference between the three groups p ≤ 0.05, but only in the spine columns. The analysis of the number of bone joints showed a significant difference in the amounts of vertebra: between the wild group with AT2 (p ≤ 0.05) and between the WT group with AT1 (p ≤ 0.01); in femur samples or p value ≤ 0.01, in both comparisons: WT-AT1 and WT-AT2. In the analysis of maxillary samples and linear bone loss, there was a significant difference between animals that suffered and suffered with p <0.001. The bone volume results showed a significant difference between the WT animals suffered and between the AT2 animals suffered and suffered (p ≤ 0.001). Regarding bone density, there was a significant difference only between WT animals and their healthy weight, p ≤ 0.01

BANKING MEMBERS:
Presidente - 2374605 - AURIGENA ANTUNES DE ARAUJO
Interno - 1660087 - BRUNO CESAR DE VASCONCELOS GURGEL
Interno - 3318536 - JOSE SANDRO PEREIRA DA SILVA