Banca de QUALIFICAÇÃO: NATÁLIA TEIXEIRA DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : NATÁLIA TEIXEIRA DA SILVA
DATE: 03/07/2020
TIME: 09:00
LOCAL: Remoto
TITLE:

Evaluation of the anti-inflammatory and antioxidant activity of Lactobacillus rhamnosus EM1107 in an experimental model of periodontitis induced in diabetic rats.

KEY WORDS:

Periodontitis. Diabetes. Probiotic. Inflammation, in vivo

PAGES: 53
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUBÁREA: Periodontia
SUMMARY:

The aim of this study was to evaluate the effects of Lactobacillus rhamnosus EM1107 on inflammation and oxidative stress in an experimental model of ligature-induced periodontitis in diabetic rats. A clinical, in vivo, randomized, blinded and controlled trial was carried out, composed of 70 male Wistar rats, which were randomly divided into five groups with 14 animals each, with the following treatments: (C1) without ligation + distilled water, (C2) ligation + distilled water, (C3) ligation + DM + distilled water, (E1) ligation + EM117, (E2) ligation + DM + EM117. Spectroscopy UV-VIS analysis was used to examine the levels of malonaldehyde (MDA), glutathione (GSH), IL-1β and TNF-α. Treatment with Lactobacillus rhamnosus EM1107 significantly reduced the concentrations of inflammatory cytokines IL-1β and TNF-α (p <0.05), but showed no benefit in modulating oxidative stress when analyzing MDA and GSH levels. This study suggests an anti-inflammatory effect of Lactobacillus rhamnosus EM1107 on ligature-induced periodontitis in diabetic rats.

BANKING MEMBERS:
Presidente - 2085732 - ANA RAFAELA LUZ DE AQUINO MARTINS
Interna - 2374605 - AURIGENA ANTUNES DE ARAUJO
Interno - 1660087 - BRUNO CESAR DE VASCONCELOS GURGEL