Banca de DEFESA: PATRÍCIA NÓBREGA GOMES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : PATRÍCIA NÓBREGA GOMES
DATE: 16/12/2019
TIME: 14:00
LOCAL: Departamento de Odontologia
TITLE:

DENTAL CHANGES IN CHILDREN WITH MICROCEPHALIA ASSOCIATED WITH CONGENITAL ZIKA VIRUS SYNDROME AND OTHER CONGENITAL INFECTIONS

KEY WORDS:

Microcephaly, Tooth Abnormalities , Zika Virus

PAGES: 78
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUBÁREA: Clínica Odontológica
SUMMARY:

The consequences of microcephaly associated or not with Congenital Zika Virus Syndrome (CZS) on the dental development of the affected child are not well known. The objectives of this study were to evaluate the frequency of dental alterations in children with microcephaly, to analyze if there is an association of dental alterations with CZS, and to verify if microcephaly is a risk factor for dental alterations. Two cross-sectional observational studies and one case-control study were performed. A single calibrated examiner evaluated the presence of dental alterations of number, shape and size, alterations in the chronology and sequence of tooth eruption, and alterations in the tooth enamel development in children with CZS and other congenital infections, as well as in normoreactive children. Information related to mothers’ pregnancies and child births were collected and a socioeconomic questionnaire was applied. Data were descriptively evaluated and chi-square test and Fisher’s exact test were used as association tests considering a significance level of 5% (studies 2 and 3). The first study sample consisted of 49 children between 7 and 35 months of age with CZS-associated microcephaly. The most prevalent alterations were related to the eruption chronology (93.9%), changes in the development of the enamel (76.1%) and the dental eruption sequence (71.7%). Next, 62 children aged 7 to 35 months with CZS-associated microcephaly (Group CZS) and other congenital infections (STORCH) comprised the sample in the second study. There was no statistically significant difference between the groups regarding change in chronology (p = 1.00), sequence of tooth eruption (p = 0.16) and changes in tooth enamel development (p = 1.00). In the case-control study, 81 normoreactive children and children with microcephaly between 30 and 35 months of age were part of the sample, which were then paired by gender and age at a 1:1 ratio after identifying the frequencies of each of the dental alterations, and then allocated to the case (presence of dental changes) or control (absence of dental changes) groups. The presence of microcephaly was statistically associated with delayed tooth eruption (p<0.001), the presence of changes in tooth eruption sequence (p<0.001) and dental enamel defects (p<0.001). It was concluded that children with CZS-associated microcephaly had delayed dental eruption, alterations in the eruptive sequence and hypomineralization of primary tooth enamel; however, a Zika virus infection was not associated with these dental changes. A microcephaly, regardless of its etiology, is a risk factor for changes related to the tooth eruption process and the development of primary tooth enamel.

It is concluded that microcephaly associated with CZS and other congenital infections is a risk factor for delayed tooth eruption, alterations in the eruptive sequence and defects in dental enamel development occurring.

BANKING MEMBERS:
Presidente - 277398 - KENIO COSTA DE LIMA
Interna - 2644142 - PATRICIA TEIXEIRA DE OLIVEIRA
Externa ao Programa - 1718635 - ISABELITA DUARTE AZEVEDO
Externo à Instituição - ANA FLÁVIA GRANVILLE GARCIA - UFPB
Externo à Instituição - HENIO GODEIRO LACERDA - UnP