Banca de QUALIFICAÇÃO: CLARICE PEREIRA DE BRITO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : CLARICE PEREIRA DE BRITO
DATE: 04/11/2019
TIME: 15:30
LOCAL: SALA IV DO DEPARTAMENTO DE ODONTOLOGIA
TITLE:

Immunohistochemical expression of p53 in oral liquid mucosa plan

KEY WORDS:

oral lichen planus, p53, immunohistochemistry

PAGES: 52
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Lichen planus (LP) is a relatively common immunologically mediated disease of unknown origin that affects the skin and often the oral mucosa. When it occurs in the mouth, it is called oral lichen planus (OLP), and presents itself as a disease of spontaneous onset and remission, of recurrent nature, being difficult to treat; lesions are mostly bilateral and symmetrical. Cases of malignant transformation in oral squamous cell carcinoma have been reported in the literature, making this lesion a potentially malignant disorder. In order to clarify the mechanisms that lead to this transformation, the role of p53 protein in the carcinogenesis of this lesion has been studied, since there is a widely proven relationship between the high rate of mutations of its gene and malignant tumors of different body tissues. Thus, the present work aims to analyze the immunohistochemical expression of p53 in oral lichen planus lesions, in order to better understand the role of this protein in the development and behavior of this lesion.

BANKING MEMBERS:
Interna - 347125 - ANA MIRYAM COSTA DE MEDEIROS
Presidente - 1258707 - ANTONIO DE LISBOA LOPES COSTA
Interno - 2859541 - PEDRO PAULO DE ANDRADE SANTOS