Banca de DEFESA: NICOLLE CAROLINE SEABRA DOS SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : NICOLLE CAROLINE SEABRA DOS SANTOS
DATE: 25/03/2026
TIME: 09:00
LOCAL: Sala de reuniões - DNUT
TITLE:

CLINICAL, DIETARY, AND METABOLOMIC PROFILE OF INDIVIDUALS WITH HEART FAILURE WITH PRESERVED AND REDUCED EJECTION FRACTION: A COMPARATIVE EXPLORATORY STUDY

KEY WORDS:

Heart Failure. Cardiac Metabolism. Diet. Metabolomics. Nutrimetabolomics. ¹H-NMR.

PAGES: 90
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Heart failure (HF) is a heterogeneous syndrome, classified into preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF), phenotypes with pathophysiological and therapeutic differences. Although diet is a central component in HF management, the metabolic mechanisms that connect dietary patterns to different phenotypes remain poorly understood. Nutrimetabolomics, by integrating food intake and circulating and urinary metabolites, allows the investigation of this interface and the identification of biomarkers sensitive to dietary exposure. The aim of this cross-sectional study was to evaluate and compare clinical, dietary, and metabolomic aspects of individuals with HFpEF and HFrEF treated on an outpatient basis. Clinical, anthropometric, biochemical, and dietary data were collected from 68 individuals with HF (24 HFpEF and 44 HFrEF). The metabolomic profile was determined by 1H nuclear magnetic resonance (NMR) spectroscopy in plasma (n = 44) and urine (n = 28), after matching for age and sex, with chemometric analysis by Orthogonal Partial Least Squares Discriminant Analysis (oPLS-DA). The sample was predominantly male, with a mean age of 55 years and overweight. The HFrEF group presented lower systolic blood pressure, greater use of diuretics and higher concentrations of transferrin, in addition to higher intake of legumes and added fats. The metabolomic profiles were globally similar between phenotypes, but with potentially discriminating metabolites. In plasma, creatine/phosphocreatine, glucose, choline/phosphocholine and glycerol stood out; in urine, threonine, formate, 2-furoylglycine and cis-aconitic acid, suggesting greater sensitivity of this matrix to detect subtle metabolic variations. The integration of diet and metabolome revealed consistent associations between food groups and pathways of energy, amino acid, and fatty acid metabolism, indicating that the metabolomic profile reflects dietary exposures and their metabolic repercussions. Taken together, these findings reinforce the potential of nutrimetabolomics to identify metabolic signatures associated with dietary patterns and to support more individualized nutritional strategies in HF.

 

COMMITTEE MEMBERS:
Externo à Instituição - ELENILSON DE GODOY ALVES FILHO - UFC
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Externa à Instituição - LJUBICA TASIC - UNICAMP
Externa ao Programa - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES - null