Banca de QUALIFICAÇÃO: LETICIA ALVES BORGES E PIRES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LETICIA ALVES BORGES E PIRES
DATE: 26/02/2025
TIME: 14:00
LOCAL: Departamento de Morfologia- CB
TITLE:

HEPATIC EVALUATION OF DIABETIC MICE TREATED WITH EXTRACT OF Spondias tuberosa Arruda

KEY WORDS:

Diabetes Mellitus experimental. Spondias tuberosa. Fígado. Morfologia. Espécies Reativas de Oxigênio.

PAGES: 41
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUMMARY:

Type 1 Diabetes Mellitus (DM1) occurs due to a failure in insulin secretion as a result of autoimmune destruction of pancreatic beta cells, causing hyperglycemia and systemic involvement. In this condition, the liver, which is commonly affected, presents with various morphofunctional alterations and an accumulation of reactive oxygen species (ROS). Due to its silent and multifactorial etiology, the pathophysiology of DM has not been fully elucidated, which limits the specificity of pharmacological therapies. Thus, alternative treatments based on medicinal plants are potentially useful for treating DM. The species Spondias tuberosa Arruda (“umbuzeiro”) has been widely used in traditional medicine to treat digestive diseases, infections and diabetes, but it has been little explored scientifically. Considering its pharmacological potential, the aim of this study was to evaluate the possible hepatoprotective effect of Spondias tuberosa Arruda extract (ExSt) in diabetic animals. 40 C57BL/6 mice were used, DM was induced by streptozotocin (65mg/kg i.p.) and ExSt was administered therapeutically or preventively for 7 consecutive weeks orally at a dose of 100mg/kg. Four groups were established: CT: Control group; DM: Diabetic group; DM/TER: Diabetic/therapeutic group; DM/PRE: Diabetic/preventive group. Serum and liver samples were sent for biochemical, morphological and molecular analysis. Preliminary results showed that diabetic animals had weight loss, increased water and feed consumption, as well as morphological changes due to liver injury; and treatment with ExSt was able to improve some of these deleterious clinical and morphological characteristics. Analysis of the lipid profile, enzymatic dosage of ROS and immunohistochemistry of liver injury markers are being evaluated to better understand the action of ExSt on the liver of diabetic mice.

COMMITTEE MEMBERS:
Presidente - 1714418 - KARINA CARLA DE PAULA MEDEIROS
Interna - 2477216 - NAISANDRA BEZERRA DA SILVA FARIAS
Externa à Instituição - Islania Giselia Albuquerque Gonçalves - UFPB