Banca de DEFESA: IANE MAIARA SOARES DE SOUZA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : IANE MAIARA SOARES DE SOUZA
DATE: 03/05/2021
TIME: 08:00
LOCAL: https://meet.google.com/ihf-mvvq-kdn
TITLE:

Development of new carriers for zeolite-based drugs: study of Faujasite, Beta and Mordenite zeolites as tools for modified isoniazid and olanzapine release.

KEY WORDS:

Zeolites, excipient, isoniazid, olanzapine, adsorption, hybrids, modified release system.

PAGES: 181
BIG AREA: Engenharias
AREA: Engenharia de Materiais e Metalúrgica
SUMMARY:

Zeolites are aluminosilicates that present as one of their main characteristics pores and
cavities of well-defined dimensions, high specific area and cation exchange capacity,
conferring ability to sieve and store molecules, making them widely applied and studied for
various purposes. Isoniazid is one of the drugs used to treat tuberculosis; an infectious and
contagious disease that has a high worldwide mortality rate has high water solubility and low
permeability. On the other hand, olanzapine is an antipsychotic agent used for the treatment of
schizophrenia and diseases of mental disorder, presenting low solubility and little oral
bioavailability. Considering these premises, this thesis has the central objective of studying
the application of the synthetic zeolites Beta, Mordenite and Faujasita as tools in the
technological improvement of the drugs isoniazid and olanzapine. For that, the zeolites and
drugs were previously characterized and the parameters related to adsorption and release were
evaluated. For the study conducted with isoniazid, adsorption kinetics were performed at
different pH's, results that were adjusted to the Langergren mathematical models, the pseudo-
second order equation and the intraparticle diffusion of the Weber and Morris model. Based
on the kinetic results, adsorption isotherms were constructed, considering the most favorable
pH and the time in which the adsorption equilibrium is reached, pH 3 and 4 hours for
Faujasita and pH 6 and 10 hours for Beta, the data isotherm were adjusted to Langmuir and
Freündlich mathematical models. Hybrid materials composed of each type of zeolite and
isoniazid were formulated and characterized by several techniques and the hybrids composed
with zeolites Faujasita and Beta studied regarding the release of isoniazid in two release
media, acid medium and phosphate buffer, with the purpose of to evaluate if these hybrids are
able to provide control over the release of isoniazid in these media. These results of the
release kinetics were adjusted to the mathematical models of Korsmeyer-Peppas and Higuchi.
In parallel, as a way to better understand the interactions between zeolite and isoniazid,
molecular modeling studies were carried out, exploring classical molecular mechanics,
applying force fields based on empirical interatomic potentials with a better fit for the drug

zeolite system, COMPASS27. Adsorption studies were also conducted with olanzapine where
the influence of pH, contact time and the initial concentration of the drug solution was
evaluated, as well as a release study. The results showed that Beta and Faujasita zeolites
showed the best retention capacity, where for Faujasita only a considerable adsorption of
olanzapine is observed with a change in the pH of the medium to 6. For the study with
olanzapine, it was also observed greater protection against thermal degradation and more
resistance at the release in the acid medium of the drug retained from the zeolite.

BANKING MEMBERS:
Externa à Instituição - ANA CLÉCIA SANTOS DE ALCÂNTARA - UFMA
Externo à Instituição - CESAR VISERAS IBORRA - UGR - Univer
Externo à Instituição - JOSÉ MANUEL PAREDES MARTÍNEZ - UGR - Univer
Externo à Instituição - MANUEL SÁNCHEZ POLO - UGR - Univer
Externo à Instituição - PABLO BOTELLA ASUNCION
Interno - 1350249 - RUBENS MARIBONDO DO NASCIMENTO
Presidente - 1308577 - SIBELE BERENICE CASTELLA PERGHER