Banca de DEFESA: ANNA KARLA DE CARVALHO FREITAS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ANNA KARLA DE CARVALHO FREITAS
DATA : 26/07/2018
HORA: 09:00
LOCAL: Sala de aulas do PPGCEM
TÍTULO:

Obtaining paligorskite / PVA based nanocomposites via tape casting for wound healing

PALAVRAS-CHAVES:

nanocomposites, tape casting, palygorskite, neomycin, drug delivery system. 

PÁGINAS: 95
GRANDE ÁREA: Engenharias
ÁREA: Engenharia de Materiais e Metalúrgica
RESUMO:

There are several efforts to develop nanocomposites that present the combination of organic polymer networks and bioactive inorganic nanoparticles for wound healing. Palygorskite has been extensively applied in drug delivery systems because it has interesting physical chemical properties. Neomycin has been considered an active principle indicated for the treatment of open wounds, which acts to inhibit the protein synthesis of gram-negative and some gram-positive bacteria. Tape casting is a technique widely used in the production of flat thin films with high specific area. In this work, ceramic tapes based on palygorskite, the drug neomycin, and the polymer PVA were obtained in order to investigate the controlled release of drug for topical administration. The stability of the suspension was analyzed by rheological tests, and the powders and ceramic tapes were characterized by X-ray fluorescence (XRF), X-ray diffraction (XRD) thermal analysis (TGA/DTA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), elemental analysis (CHN-S), scanning electron microscopy (SEM-FEG). Tests of antimicrobial activity and minimum bactericidal concentration were performed in order to investigate the potential for drug inhibition in the sheets. Finally, calculations of classical mechanics were carried out in order to estimate the energy, for possible calculation of adsorption energy. According to the rheology results, a pseudoplastic behavior was observed, suitable for the tape casting technique. Reflection peaks related to the paligorskite phases - H₉AlMgO₁₅Si₄, of orthorhombic structure (JCPDS 98-007-7211) and quartz - SiO₂, of hexagonal structure (JCPDS 98-003-5110) were found. DSC analysis identified exothermic peaks characteristic of neomycin in the Pal-Neo hybrid. Elemental analysis results showed that less than 3% of neomycin was incorporated into palygorskite. Tests of antimicrobial activity and minimum bactericidal concentration demonstrated that the Pal-Neo hybrid had an inhibitory effect on the growth of bacteria, proving being capable of damaging the cytoplasmic membrane of the tested bacteria.

MEMBROS DA BANCA:
Externo à Instituição - Ana Paula da Silva Peres - UFRN
Externo à Instituição - Antonio Carlos Silva da Costa - UFRN
Externo à Instituição - CESAR VISERAS IBORRA - UGR - Univer
Interno - 1308577 - SIBELE BERENICE CASTELLA PERGHER
Presidente - 1149564 - WILSON ACCHAR