Banca de DEFESA: FERNANDA DE CASTRO TEIXEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : FERNANDA DE CASTRO TEIXEIRA
DATE: 16/12/2025
TIME: 09:00
LOCAL: Departamento de Enfermagem - Anfiteatro I
TITLE:

EFFECTIVENESS OF IRON SUPPLEMENTATION IN ANEMIC PATIENTS IN THE PRE-OPERATIVE CARDIAC SURGERY SETTING: SYSTEMATIC REVIEW AND META-ANALYSIS

 

KEY WORDS:

iron deficiency; cardiac surgery; iron-deficiency anemia; extracorporeal circulation; perioperative period.

 

PAGES: 74
BIG AREA: Ciências da Saúde
AREA: Enfermagem
SUMMARY:

Iron deficiency is one of the most frequent comorbidities in patients with heart failure and represents an important risk factor for complications during the perioperative period of cardiac surgeries. Considering the
role of the perfusion nurse in blood management and in the prevention of transfusion-related events, it is relevant to evaluate therapeutic strategies that contribute to the correction of preoperative anemia. Thus, this study aimed to assess the effectiveness of iron supplementation in anemic patients undergoing cardiac surgery. This is a systematic review with meta-analysis of randomized clinical trials, conducted according to PRISMA recommendations and registered in PROSPERO under number CRD42024568295. The searches were
performed in the Cochrane Library, LILACS, PubMed, SCIELO, Science Direct, Scopus, CINAHL, Web of Science, and Wiley Online Library databases, with no restrictions on language or publication period. Studies were included if they analyzed adult patients diagnosed with anemia and heart failure undergoing cardiac surgery who received iron supplementation orally or intravenously in the preoperative period. Quantitative analysis was performed using R software, applying fixed- and random-effects models according to the level of heterogeneity (I²). Risk of bias was assessed using the ROB2 tool, and the certainty of evidence was evaluated through the GRADE approach. The final sample consisted of seven studies that met the eligibility criteria. Most participants were female, aged between 18 and 67 years. The meta-analysis results showed no statistically significant differences between the control and intervention groups for the primary outcomes regarding the occurrence of atrial fibrillation (OR = 0.75; 95% CI: 0.32–1.77; I² = 0%). Similarly, no significant differences were found for hospital length of stay (mean difference = –2.50 days; 95% CI: –7.27 to 2.27; I² = 72.7%) or intensive care unit stay (mean difference = –0.25 days; 95% CI: –1.67 to 1.17; I² = 93.7%). For mortality rate, the meta-analysis indicated an OR = 0.47 (95% CI: 0.10–2.28; I² = 0%), suggesting a trend toward risk reduction in the group that received iron, although not statistically significant. It is concluded that preoperative intravenous iron supplementation in cardiac surgery appears to be a promising strategy to reduce complications and improve recovery in anemic patients, but further studies with larger samples and standardized methodological designs are still required.

 

COMMITTEE MEMBERS:
Interna - 1299781 - ALEXSANDRA RODRIGUES FEIJAO
Interna - 2553720 - KATIA REGINA BARROS RIBEIRO
Externa à Instituição - NAHADJA TAHAYNARA BARROS LEAL - EBSERH
Presidente - 3578073 - RODRIGO ASSIS NEVES DANTAS