Clinical Validation of the Nursing Diagnosis "Risk for Impaired Liver Function" in People with HIV Using Antiretrovirals.
Nursing diagnoses. Liver disease. Risk factors. Human Immunodeficiency Virus.
The combined use of antiretrovirals is the cornerstone of treatment for people living with HIV; however, the risk of adverse effects, particularly on the liver, requires attention. Individuals with HIV may develop hepatic disorders such as cirrhosis and liver failure. To ensure safe and high-quality care for this population, it is essential to emphasize the Nursing Process as a tool for professional practice. The use of standardized nursing language, such as the NANDA-I taxonomy, is crucial to qualify the care process. The nursing diagnosis Risk for Impaired Liver Function may occur in these individuals due to both the direct action of the virus and the toxicity associated with continuous antiretroviral therapy, which can compromise hepatic cells. In this context, early identification of risk factors that may contribute to this condition is essential to prevent liver damage and reduce potential clinical complications. Therefore, the objective of this study is to clinically validate the nursing diagnosis Risk for Impaired Liver Function in people living with HIV undergoing antiretroviral therapy. This is a retrospective case- control study to be conducted at a Specialized HIV/AIDS Care Service, with a sample of 348 individuals, comprising 174 cases and 174 controls. Data will be collected from December 2025 to July 2026 using an instrument addressing risk factors, associated conditions, and populations at risk for impaired liver function. Variables will be analyzed using descriptive and inferential statistics. The study will be submitted to the Research Ethics Committee of the Federal University of Rio Grande do Norte for approval.