TCD4+Th9 RESPONSE ANALYSIS AND BAX IMMUNOEXPRESSION IN ORAL LICHEN PLANUS
Oral plan liquen, BAX protein; Apoptosis.
Lichen planus is a chronic dermatological disease of unclarified pathogenesis that often affects the skin and in some cases the oral mucosa, and when this happens, it is called oral lichen planus – LPO. Clinically, LPO is classified into six well-identified patterns: plaque, reticular, bullous, atrophic, papular and erosive. The most common being the reticular and erosive types. The activation of TCD4+ lymphocytes in LPO can induce ceratinocytes to the apoptosis process through the cytotoxic immunological response Thus, the present research aims to evaluate the immunohistochemical expression of IL-9, MMP9 and BAX proteins in LPO. Thus, it is intended to contribute to a greater understanding of the possible cellular mechanisms involved in the etiopathogenesis of this lesion, in order to enable a more effective treatment, and thus a better prognosis for these patients.