Banca de QUALIFICAÇÃO: HANNAH GIL DE FARIAS MORAIS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : HANNAH GIL DE FARIAS MORAIS
DATE: 28/08/2024
TIME: 14:30
LOCAL: SALA DE AULA DA PATOLOGIA ORAL
TITLE:

BIDIRECTIONAL CROSSTALK BETWEEN MESENCHYMAL-EPITHELIAL TRANSITION AND TUMOR MICROENVIRONMENT IN ORAL TONGUE SQUAMOUS CELL CARCINOMA: AN IMMUNOHISTOCHEMICAL STUDY

KEY WORDS:

Oral Squamous cell carcinoma. Oral cancer. Mesenchymal-epithelial transition. Tumor microenvironment.

PAGES: 47
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

The search for biomarkers that contribute to a better understanding of oral carcinogenesis is a constant challenge among researchers in the field. In this context, epithelial-mesenchymal transition (EMT) stands out as a complex and reversible biological process, which contributes to tumor progression, invasion of neoplastic cells and resistance to therapy. A challenging new aspect of EMT research is the investigation of its interaction with the tumor microenvironment (MAT). Components of MAT may function as regulators of hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, dysregulation of energy metabolism, resistance to immunological detection and destruction, and activation of invasion and metastasis. Therefore, this study aims to investigate the bidirectional crosstalk between MET status and MAT markers in oral tongue squamous cell carcinomas (OSCC), evaluating their respective associations with clinicopathological and prognostic parameters, in order to better understand how the interaction of neoplastic cells with MAT can influence the neoplastic progression of these neoplasms. The immunoexpressions of E-cadherin, N-cadherin, TGF-β, α-SMA, CD163, FOXP3, PD-1 and PD-L1 proteins will be analyzed in 64 CCELO specimens. Possible associations between the expression pattern of these proteins and different histopathological grades, clinical staging, occurrence of locoregional recurrence and overall and disease-free survival will be investigated. With the results obtained in this study, it is expected to advance the understanding of the bidirectional crosstalk between MET and MAT in oral carcinogenesis, providing theoretical support for the improvement of therapeutic strategies.

COMMITTEE MEMBERS:
Presidente - 350484 - ROSEANA DE ALMEIDA FREITAS
Interna - 3218128 - AMANDA KATARINNY GOES GONZAGA
Interna - 1121806 - MARIA LUIZA DINIZ DE SOUSA LOPES