Evaluation of the anti-inflammatory and antioxidant activity of Lactobacillus rhamnosus EM1107 in an experimental model of periodontitis induced in diabetic rats.
Periodontitis. Diabetes. Probiotic. Inflammation. Biology
Periodontal disease and diabetes share similar chronic immunoinflammatory mechanisms, so probiotic therapy has been suggested as an alternative or complement to non-surgical periodontal therapy. A clinical, in vivo, randomized, blinded and controlled trial was carried out, composed of 70 male Wistar rats, which were randomly divided into five groups with 14 animals each, with the following treatments: (C1) without ligation + distilled water, (C2) ligation + distilled water, (C3) ligation + DM + distilled water, (E1) ligation + EM117, (E2) ligation + DM + EM117. Spectroscopy UV-VIS analysis was used to examine the gingival levels of malonaldehyde (MDA), glutathione (GSH), IL-1β and TNF-α. Treatment with Lactobacillus rhamnosus EM1107 significantly reduced the concentrations of inflammatory cytokines IL-1β and TNF-α (p <0.05), but showed no benefit in modulating oxidative stress when analyzing MDA and GSH levels. This study suggests an anti-inflammatory effect of Lactobacillus rhamnosus EM1107 on ligature-induced periodontitis in diabetic rats.