Evaluation of the anti-inflammatory and antioxidant activity of Lactobacillus rhamnosus EM1107 in an experimental model of periodontitis induced in diabetic rats.
Periodontitis. Diabetes. Probiotic. Inflammation, in vivo
The aim of this study was to evaluate the effects of Lactobacillus rhamnosus EM1107 on inflammation and oxidative stress in an experimental model of ligature-induced periodontitis in diabetic rats. A clinical, in vivo, randomized, blinded and controlled trial was carried out, composed of 70 male Wistar rats, which were randomly divided into five groups with 14 animals each, with the following treatments: (C1) without ligation + distilled water, (C2) ligation + distilled water, (C3) ligation + DM + distilled water, (E1) ligation + EM117, (E2) ligation + DM + EM117. Spectroscopy UV-VIS analysis was used to examine the levels of malonaldehyde (MDA), glutathione (GSH), IL-1β and TNF-α. Treatment with Lactobacillus rhamnosus EM1107 significantly reduced the concentrations of inflammatory cytokines IL-1β and TNF-α (p <0.05), but showed no benefit in modulating oxidative stress when analyzing MDA and GSH levels. This study suggests an anti-inflammatory effect of Lactobacillus rhamnosus EM1107 on ligature-induced periodontitis in diabetic rats.