Efficacy of adjuvant photodynamic therapy in the treatment of patients with periodontitis using two distinct photosensitizers: chloro-aluminum phthalocyanine and methylene blue
photochemotherapy, periodontal disease, periodontitis, treatment outcome
Different photosensitizers have been proposed in the use of Antimicrobial Photodynamic Therapy (aPDT). In addition, aPDT has been suggested as a possible adjuvant to basic periodontal therapy. Objective: to evaluate the efficacy of adjuvant aPDT to the basic periodontal treatment of periodontal clinical parameters in patients with periodontitis using two photosensitizers: Chlorine-Aluminum Phthalocyanine (AlClPc) and Methylene Blue (MB). Material and Methods: this randomized, double - blind, parallel trial evaluated 35 patients: 9 in the control group (SRP only), 15 in the test group 1 (SRP + aPDT - AlClPc) and 11 in the test group 2 (SRP + aPDT - MB). Each patient had between 2 or 3 diseased periodontal sites (PS≥5mm), in a total of 117 sites. The aPDT for the two test groups was applied once only after the completion of the SRP sessions. Visible plaque index (PI), bleeding on probing (BOP), depth of probing (PD) and clinical attachment level (CAL) were evaluated before treatment at T0 and after 3 months (T3) times and 6 months (T6). For the intragroup analysis, a Kruskall Wallis test was performed, and the applied test was Mann-Whitney; already for intergroup analysis, Friedman's test was applied with post-test of Wilcoxon and Mann-Whitney.