Comparative study between the chloro-aluminum phthalocyanine and methylene blue photosensitizers used in the photodynamic therapy adjuvant to the treatment of patients with periodontitis.
photochemotherapy, periodontal disease, periodontitis, treatment outcome
Several photosensitizing drugs have been proposed in the literature in the clinical application of Antimicrobial Photodynamic Therapy (aPDT). Objective: to evaluate longitudinally the effect of photosensitizer Chloro-Aluminum Phthalocyanine (AlClFc) in comparison to Methylene Blue on TFDA as an adjuvant to basic periodontal treatment on periodontal clinical parameters in patients with periodontitis. Material and Methods: This randomized, double-blind, parallel, longitudinal, and prospective trial evaluated 44 patients: 20 in the test 1 group (SRP+aPDT– MB), 15 in the test 2 group (SRP+ aPDT – AlClFc) and 9 in the control group (SRP alone). Each patient had at least 2 diseased periodontal sites (PS≥5mm), totaling 103 sites. The aPDT was applied once only after the completion of the SRP sessions. The indexes of oral hygiene - visible plaque index [PI], gingival bleeding index [GBI], and periodontal clinical parameters - bleeding on probing [BOP], depth of probing [PD] and clinical attachment level [CAL] - were evaluated before treatment at T0, and after 3 months (T3) and 6 months (T6) times.