Banca de QUALIFICAÇÃO: FRANCISCO CLÉBISON CHAVES LOPES

PROFILE OF ANTIMICROBIAL USE IN NEONATAL INTENSIVE CARE UNITS: A SCOPE REVIEW

Anti-Infectives. Neonatal Intensive Care Units. Use of Medications.

Newborns are especially susceptible to infections due to the immaturity of the immune system, aggravated by factors such as invasive procedures, length of hospital stay and low birth weight. As a result, studies investigating the pattern of medication use in Neonatal Intensive Care Units indicate that systemic anti-infective agents are the most commonly used class of medications. The susceptibility of the population, the lack of consensus in definitions and the variability in etiological agents between regions make it difficult to make global recommendations, resulting in heterogeneous management of neonatal infections. Therefore, the objective of this study is to describe the profile of the use of antimicrobials in Neonatal Intensive Care Units. This is a scoping review conducted in accordance with the methodology proposed by the Joana Briggs Institute (JBI). The following databases will be included: LILACS via Virtual Health Library; BASIS; MEDLINE/PubMed via National Library of Medicine; Scientific Electronic Library Online (SciELO) via Web of Science; Web of Science and Scopus. To identify gray literature, digital repositories will be consulted. The search will be carried out using descriptors, combined with the Boolean operators “OR” and “AND”, related to the acronym PCC: population, concept and context. Identified studies will be uploaded to the Rayyan app and duplicates removed. The selection of studies and data extraction will be conducted by two independent reviewers. We hope that the results will make it possible to understand how these drugs are being used in different countries, considering aspects such as patient characteristics, clinical protocols adopted and health policies that influence the choice and use of antimicrobials. This study could serve as a basis for the formulation of policies and guidelines, in addition to providing evidence that will support health professionals in making decisions about the use of antimicrobials, promoting safer and more effective clinical practice.