Banca de QUALIFICAÇÃO: LUANA BARBOSA DA CRUZ

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : LUANA BARBOSA DA CRUZ
DATE: 17/01/2023
TIME: 09:00
LOCAL: meet.google.com/sin-fnfr-yqw
TITLE:

Tape casting of hydroxyapatite and tricalcium phosphate membranes with added manganese for bone regeneration

KEY WORDS:

Tape Casting, biomaterials, manganese, TCP, hydroxyapatite.

PAGES: 60
BIG AREA: Engenharias
AREA: Engenharia de Materiais e Metalúrgica
SUBÁREA: Materiais Não-Metálicos
SPECIALTY: Cerâmicos
SUMMARY:

The growing increase of damage to bone tissues characterizes a huge challenge for the repair of the lesions caused by the slow rates of healing, especially in the elderly population, causing a decrease in wellbeing and high cost of treatment. Several alternatives have been studied to promote an improvement in bone regeneration, among them, one of the most promising is the use of biomaterials, starting with the use of barrier membranes. They are responsible for tissue integration, once they prevent the invasion of fibroblasts by providing stability to bone grafts and guarantee a protection for the osteogenesis process, also known as guided bone regeneration, accelerating the process. The manufacture of calcium phosphate membranes has been increasingly studied due to a chemical and biological similarity with the bone constitution, as well as good cell adhesion and relatively low cost. TCP and HA have biological characteristics of high biocompatibility and excellent resorption by the organism, acting as a scaffold for bone growth, and manganese has the ability to develop magnetic properties and control cellular activities in bone regeneration, making them effective for use as barrier membranes. In this work, studies were performed regarding the production through the Tape Casting method of hydroxyapatite and tricalcium phosphate membranes with and without manganese addition for bone regeneration enhancement. The ceramic suspension was the first part characterized, being done through the study of the rheological behavior. The membrane was the second step to be characterized and it occurred through X-ray diffraction analysis (XRD), thermogravimetric analysis (ATG/ ADT), scanning electron microscopy (SEM- FEG), degree of intumescence, bioactivity and cytotoxicity. The results obtained showed a suspension of pseudoplastic behavior suitable for the process via Tape Casting, the membranes were flexible, with characteristic phases, biodegradable, biocompatible, non-toxic, with good water absorption, which is ideal for the desired application.

COMMITTEE MEMBERS:
Interno - 1149564 - WILSON ACCHAR
Externo à Instituição - CLAWSIO ROGERIO CRUZ DE SOUSA - UFERSA
Externa à Instituição - SHEYLA KAROLINA JUSTINO MARQUES - IFAl
Externo à Instituição - VAMBERTO MONTEIRO DA SILVA - IFPB