Banca de QUALIFICAÇÃO: ISABELA KAROLINY CALIXTO DE SOUZA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ISABELA KAROLINY CALIXTO DE SOUZA
DATE: 15/06/2023
TIME: 15:00
LOCAL: https://meet.google.com/xxr-teis-uyw
TITLE:

Association of polypharmacy and potentially inappropriate medication use with physical activity and sedentary time in older adults

KEY WORDS:

Keywords: Multiple medication; Exercise; Sitting; Chronic diseases; Aging.

PAGES: 75
BIG AREA: Ciências da Saúde
AREA: Educação Física
SUMMARY:

Objective: Study 1: To map out the studies that have investigated the associations of polypharmacy and/or potentially inappropriate medication (PIM) use with physical activity and sedentary time in older adults; study 2: to investigate the association between polypharmacy with physical activity and sedentary time in community-dwelling older adults. In this qualification stage, the results of study 1 will be presented, as well as preliminary results and future perspectives of study 2. Methods: Study 1: Scoping review. Four databases (PubMed, Embase, Web of Science, and Scopus) were searched. Inclusion criteria: observational studies that included older adults (≥60 years); English, Portuguese, and Spanish languages; any definition of polypharmacy; implicit and explicit criteria of PIM use; self-reported and/or objectively-measured physical activity and sedentary time measures. Study 2: Cross-sectional study involving youngest-old adults (60-80 years old) without known cardiovascular diseases residing in Natal-RN. Three criteria were used to define polypharmacy: the use of three, four, and five daily medications. The analyses included 451 participants with self-reported measures of physical activity and sedentary time, and 244 participants with accelerometer-based measures. Linear regressions were used for data analysis. Results: Study 1: Fourteen cross-sectional studies were included; 11 defined polypharmacy as ³5 medications, and its prevalence ranged from 9.5% to 57%. No study reported information on PIM use. Most studies included participants aged <80 years. Twelve studies included self-reported measures of physical activity (only seven used validated questionnaires). Ten studies included analyses adjusted for cofounders, and nine considered polypharmacy as an outcome. All of them showed an inverse association between physical activity and polypharmacy. Study 2: No significant associations were observed between polypharmacy and physical activity or sedentary time, both in self-reported measures and accelerometer data (p > 0.05). Conclusions: The studies assessing the relationship between polypharmacy and physical activity are scarce, cross-sectional, mainly including youngest-old adults, and use self-reported measures of physical activity. This limited evidence suggests that there may be an inverse association between physical activity and polypharmacy, but is unclear whether this relationship is bidirectional. The relationship between PIM use and physical activity and sedentary time is unknown (study 1). In apparently healthy youngest-old adults, preliminary results demonstrate no significant association between polypharmacy and physical activity and sedentary time levels (study 2).

COMMITTEE MEMBERS:
Presidente - 2682821 - EDUARDO CALDAS COSTA
Interno - 1989744 - HASSAN MOHAMED ELSANGEDY
Externo ao Programa - 1460020 - ALVARO CAMPOS CAVALCANTI MACIEL - UFRNExterna à Instituição - CÍNTIA EHLERS BOTTON - UFC
Externo à Instituição - FILIPE FERNANDES OLIVEIRA DANTAS - UNI-RN