Banca de DEFESA: BRUNA RODRIGUES MONTEIRO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : BRUNA RODRIGUES MONTEIRO
DATE: 18/12/2023
TIME: 14:00
LOCAL: Departamento de Enfermagem - DENF
TITLE:

Prevalence of congenital syphilis in newborns in the global context: systematic review.

KEY WORDS:

Congenital Syphilis; Vertical transmission; Gestation; Syphilis.

PAGES: 120
BIG AREA: Ciências da Saúde
AREA: Enfermagem
SUMMARY:

Objective: Detect the prevalence of congenital syphilis in newborns in the global context. Method: This is a systematic review. To construct the guiding question, I use the PECOT mnemonic (Population, Exposure, Comparator, Results, Type of Study). After formulating the mnemonic, the review presented the following research question: “What is the prevalence of congenital syphilis in newborns in the global context? ”. The search was carried out in the following databases: Embase, PubMed, Scopus, Ebsco, Web of Science, Latin American and Caribbean Literature in Health Sciences (LILACS). As a search strategy, a combination of descriptors indexed in the Medical Subject Headings (MeSH) was adopted: Pregnancy; Vertical Transmission of Infectious Diseases Syphilis; Observational study, mediated by the Boolean operator “AND” and “OR”. Observational studies on the vertical transmission of gestational syphilis and the association of gestational syphilis with congenital syphilis were included as inclusion criteria. There were no language or time restrictions for study selection. The systematic review period was six months. Article selection and data extraction were performed by two independent, blinded reviewers using Rayyan Intelligent Systematic Review software and based on the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) flowchart. To evaluate the quality of the evidence of the included data, the Grading of Recommendations Assessment, Developing and Assessment (GRADE) method was chosen, while the Newcastle-Ottawa Scale was used to analyze the risk of bias. The review protocol was sent to the database of the International Prospective Registry of Systematic Reviews with registration number CRD 42022349359 and since it involved research data already published in a scientific database, the Research Ethics Committee was exempt. Results: In total, 6,268 studies
were identified in the databases, after using the PRISMA software and based on the PRISMA flow chart. The sample was composed of 30 studies (16 cohort studies; 04 case-control; 10 cross-sectional studies) that involved 15,593 pregnant women diagnosed with gestational syphilis who transmitted the infection vertically. The studies were carried out mainly in China, Brazil and the United States of America, from 1995 to 2023. As a diagnostic test for gestational syphilis, the rapid treponemal test is referred to as a diagnostic tool, while benzathine penicillin G is the first drug of choice . for the treatment of syphilis. As an effect of transmission, the complications found in newborns were: Congenital syphilis and adverse events associated with prematurity, low birth weight and fetal/neonatal mortality. The main cause of verticalization was associated with incomplete treatment of syphilis during pregnancy and late diagnosis of the disease in the third trimester. Conclusion: Despite the high number of studies identified in the databases, regardless of period and language, only 30 studies contextualize the global reality of congenital syphilis and its association with gestational syphilis. However, the outcome of congenital syphilis was represented by late diagnosis and treatment of gestational syphilis.

COMMITTEE MEMBERS:
Externa à Instituição - CAROLINA PEREIRA DA CUNHA SOUSA - UnB
Interna - 1995800 - ERIKA SIMONE GALVAO PINTO
Externo à Instituição - KLEYTON SANTOS DE MEDEIROS - LNRCC
Externa ao Programa - 4149590 - MARIA DE LOURDES COSTA DA SILVA - nullPresidente - 3168491 - NILBA LIMA DE SOUZA