Banca de DEFESA: HOUSEMBERG DONANVAM DA SILVA FERREIRA
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : HOUSEMBERG DONANVAM DA SILVA FERREIRA
DATE: 29/02/2024
TIME: 09:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/qpn-etgm-wsb
TITLE:
Copper Sulfate (CuSO4): An Efficient Reagent in Organic Synthesis
KEY WORDS:
Synthesis, Hydrazones, Oxadiazois, 1,2,3-triazole, Cancer, Hepatitis C.
PAGES: 156
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Nitrogenous aromatic heterocycles are biologically active chemical structures and
comprise around 80% of medicines currently marketed. Based on this premise, the present
work addresses two groups of biologically active nitrogenous aromatic heterocycles
known as triazoles and hydrazones. Chapter one covers the entire process of synthesis of
1,2,3-triazole compounds derived from amino acids, which, through four reaction steps
starting from the amino acid phenylalanine, resulted in the formation of five new 1,2,3-
triazole compounds with Yields vary from 22% to 55%, and these, based on virtual
screening studies, have possible biological activity against the virus that causes hepatitis
C. However, concrete biological evaluation data are still needed to prove this hypothesis.
In the second chapter, the syntheses of hydrazonic compounds will be discussed starting
from the drug isoniazid, where nine hydrazonic compounds were formed from reactions
with different aromatic aldehydes with yields varying from 25% to 92%, and from virtual
screening studies involving hydrazones produced in this work, the hypothesis was
formulated that these molecules have antineoplastic activity. Furthermore, due to the vast
biological potential that these molecules present, the modulatory activity of antimicrobial
resistance was evaluated based on analyzes of strains resistant to commercialized
antimicrobials, and it was noted that the molecules produced in this work had a synergistic
effect with the drugs analyzed, modulating resistance. of the bacterial strains, however,
IC50 data is still awaited to complete this study. A new stage of reactions involving
hydrazonic compounds was also carried out to form their oxadiazole derivatives, where
a compound was obtained with a yield of 93%.
COMMITTEE MEMBERS:
Presidente - 1571756 - ALESSANDRO KAPPEL JORDAO
Externa ao Programa - 1679481 - ANA PAULA BARRETO GOMES - nullExterno à Instituição - DANIEL TADEU GOMES GONZAGA - UERJ