Banca de DEFESA: ANTONIA PEREIRA ROSA NETA
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANTONIA PEREIRA ROSA NETA
DATE: 27/02/2024
TIME: 14:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/mfq-afmr-htc
TITLE:
Biomarkers for Arrhythmogenic Right Ventricular Cardiomyopathy
through bioinformatic analysis
KEY WORDS:
Arrhythmogenic right ventricular cardiomyopathy. CAVD. RNAms.miRNAs.Biomarkers.
PAGES: 85
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Arrhythmogenic right ventricular cardiomyopathy (CAVD) is a disease characterized
pathologically by fibrofatty replacement primarily in the right ventricle of normal heart tissue
and clinically by potentially fatal ventricular arrhythmias in apparently healthy young people.
The prevalence of the disease was estimated at 1:5,000 individuals. CAVD has a very difficult
diagnosis due to the need to investigate and differentiate the results of several
electrocardiographic tests that are also common to other heart diseases. The aim of this work is
to analyze miRNA and RNAm expression profile data from patients with CAVD and provide
insights on the pathophysiology of CAVD and new connections of the miRNAsRNAms
network for further investigation and screening of efficient biomarkers for CAVD. For this,
GEO dataset databases and bioinformatics tools were used to track 47 DEGs in CAVD. Then,
Gene Ontology enrichment analysis (GO) and protein-protein interaction analysis (PPI) were
performed. Finally, 3 most important small molecules (hsa-miR-21-5p, hsa-miR-34a-5p, hsa
miR-4443, hsa-miR-486-5p) were identified that show expression in tissue and plasma and have
disease-related molecular mechanisms in the disease cycle and could serve as a promising
biomarker for CAVD.
COMMITTEE MEMBERS:
Presidente - 2087759 - ANDRE DUCATI LUCHESSI
Interna - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Externo à Instituição - OTAVIO CABRAL MARQUES - USP