Banca de DEFESA: HERIKS GOMES RIBEIRO
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : HERIKS GOMES RIBEIRO
DATE: 20/02/2024
TIME: 14:00
LOCAL: Link de acesso para videoconferência: meet.google.com/fra-mcux-iff
TITLE:
Unraveling the role of miRNAs as biomarkers in Chagas cardiomyopathy: Insights into molecular pathophysiology
KEY WORDS:
Chagas cardiomyopathy; miRNA; biomarkers; detection; progression
PAGES: 86
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Introduction: Chagas cardiomyopathy (CC) is a severe form of Chagas disease (DC)
and one of the main causes of cardiovascular morbidity and mortality. Dysregulation
of the immune response leads to cardiac remodeling and functional changes, resulting
in life-threatening complications. Conventional diagnostic methods have limitations
and assessing therapeutic response is still a challenge. MicroRNAs (miRNAs),
important regulators of gene expression, have potential as biomarkers for diagnosis
and prognosis. Objective: This review aims to summarize experimental findings on
the expression of differential miRNAs in CC and explore the potential of these miRNAs
as biomarkers in Chagas disease. Methods: The search was carried out in the public
database of the United States National Library of Medicine (MEDLINE/PubMed) using
the terms “Chagas cardiomyopathy” OR “Chagas Disease” AND “microRNA” OR
“miRNA” OR “miR”. Furthermore, a bioinformatics analysis was performed to
investigate miRNA-target interactions and explore Gene Ontology (GO) enrichment
pathways of biological processes and molecular functions. Results: miR-21, miR-
146b, miR-146a, and miR-155 exhibited consistently upregulation, whereas miR-145
was upregulated at CC levels. These specific miRNAs have been associated with
fibrosis, immune response and inflammatory processes in cardiac tissue. Conclusion:
In this review, we highlight the role of frequent miRNAs in the studies developed. In
addition to presenting biological functions in the CC context, these miRNAs were
shown to be potential biomarkers for diagnosis, disease progression and monitoring of
antiparasitic treatment.
COMMITTEE MEMBERS:
Externa à Instituição - ISABELLE CRISTINA CLEMENTE DOS SANTOS - LACEN
Externa à Instituição - JULIANA DE ASSIS SILVA GOMES ESTANISLAU - UFMG
Presidente - 1804884 - VIVIAN NOGUEIRA SILBIGER