Banca de DEFESA: TÁSSYO LEANDRO DA SILVA
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : TÁSSYO LEANDRO DA SILVA
DATE: 24/11/2023
TIME: 14:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/ugf-zkmx-izu
TITLE:
Antioxidant and skin color harmonization cosmetic formulations: Prosopis juliflora extract fruit as a new multifunctional bioactive
KEY WORDS:
Mesquite; Prosopis juliflora; Antioxidant; Cosmetics; Melanogenesis.
PAGES: 141
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
The rich biodiversity of plant species in Brazil enables studies for the development of
products containing natural compounds. Prosopis juliflora, more commonly known as
mesquite, is a plant that was brought from Peru, and introduced and spread
throughout the semi-arid region of the northeast, becoming an invasive species in the
Caatinga. Studies report antimicrobial, antioxidant, antimalarial, and antitumor
actions among others, due to the presence of secondary metabolites such as
alkaloids, terpenoids, tannins, and flavonoids, present in different parts of this plant.
Some of these metabolites can be used by the cosmetic industry for different
activities. This work aims to evaluate the antioxidant and antityrosinase activity of P.
juliflora fruit extract and develop cosmetic formulations to harmonize skin color. To
this end, the extract obtained using previously standardized methodologies was
evaluated for the concentration of total flavonoids (1.71 ± 0.26 µg EQ/mg) and 0.21 ±
0.01 mg EAG/g of phenolic compounds. Furthermore, the extract studied was
characterized by LC-MS-TOF. The in vitro safety of the extract was evaluated using
cellular cytotoxicity tests and the samples did not show cytotoxic effects. The in vitro
antioxidant activity was evaluated using different methodologies and demonstrated
the ability to block the oxidation cascade in the initiation and propagation phases.
The antityrosinase action was evaluated using enzymatic methodology and the
extract showed an inhibition activity of 62.48 ± 2.09 at a concentration of 30.00
mg/ml. Formulations with Disodium EDTA, Phenoxyethanol (and) Ethylhexyl
Glycerin, Distilled Water, Sodium Acrylates Copolymer Lecithin, Polyacrylamide (and)
C13-14 Isoparaffin (and) Laureth-7 and 3.00% of the studied plant extract were
subjected to preliminary and accelerated stability tests. The formulations were stable
in accelerated stability tests after a period of 60 days. This research, in addition to
contributing scientifically by demonstrating the use of a Caatinga plant in antioxidant
cosmetic products and for homogenizing skin color, will also contribute to adding
value to the P. juliflora production chain, giving value to aspects of Brazilian
environmental, social and biodiversity responsibilities.
COMMITTEE MEMBERS:
Externo à Instituição - JULIANO GERALDO AMARAL - UFBA
Presidente - 1714294 - MARCIO FERRARI
Externa à Instituição - STELLA MARIA ANDRADE GOMES BARRETO