Banca de QUALIFICAÇÃO: EMILY THAYS DA SILVA RODRIGUES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : EMILY THAYS DA SILVA RODRIGUES
DATE: 10/11/2023
TIME: 08:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/dwi-cfdr-hkh
TITLE:

DEVELOPMENT OF A MULTI-EPITOPE ANTIGENIC PROTOTYPE FOR CHAGAS DISEASE THROUGH AN IMMUNOINFORMATICS END MOLECULAR MODELING APPROACH

KEY WORDS:

Vaccines; Trypanosoma cruzi; Chagas disease; Epitope prediction; Bioinformatics.

PAGES: 79
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Chagas Disease, caused by the parasite Trypanosoma cruzi, is a widely neglected tropical disease in Latin America. Despite vector control strategies, new transmission mechanisms continue to play a crucial role in the disease's spread. Current treatment with benznidazole faces challenges due to adverse reactions, emphasizing the urgent need for a more effective approach. In this context, this study aims to identify conserved and immunogenic epitopes in key T. cruzi proteins and to plan a multi-epitope antigen prototype through immunoinformatics and molecular modeling techniques. Preliminary results highlight promising epitopes in proteins such as Cruzipain, Glutathione S-transferase (Tc52), Prolyl Oligopeptidase (Tc80), and Trans-sialidase (TS). Additionally, an antigen prototype has been designed, distinguished by its physicochemical properties that favor stability, effectiveness, and the ability to induce an appropriate immune response. However, it is crucial to emphasize the pressing need for experimental validation to ensure the effectiveness and safety of the predicted antigen prototype. Therefore, this study not only expands the understanding of the immune response to T. cruzi but also rekindles hope for an effective vaccine capable of effectively controlling the spread of Chagas disease. This promising perspective not only improves the quality of life for affected populations but also contributes to the fight against neglected diseases.

COMMITTEE MEMBERS:
Externa à Instituição - CLAUDIA JASSICA GONÇALVES MORENO - NOVA
Presidente - 1893445 - EUZEBIO GUIMARAES BARBOSA
Externa ao Programa - 051.067.144-60 - KATYANNA SALES BEZERRA