Banca de QUALIFICAÇÃO: HOUSEMBERG DONANVAM DA SILVA FERREIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : HOUSEMBERG DONANVAM DA SILVA FERREIRA
DATE: 29/09/2023
TIME: 14:30
LOCAL: Sessão de videoconferência: https://meet.google.com/vbe-fnpf-rha
TITLE:

PLANNING, SYNTHESIS AND BIOLOGICAL EVALUATION OF HYDRAZONES AND 1,2,3-TRIAZOLES

KEY WORDS:

Cancer, Hepatitis C, Synthesis, Hydrazones, Oxadiazois, 1-2-3-triazole.

PAGES: 114
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

In this work, two different topics of extreme relevance involving serious pathologies that
address advanced and updated treatments will be addressed. When talking about cancer
it is understood that it is a disease caused by the appearance of neoplastic cells forming a
malignant tumor, there are more than 100 diseases related to this disordered growth,
where, many times, a different treatment is necessary to reach and treat its most diverse
Therefore, thinking about the problem of the disease that causes the most deaths before
the age of 70, according to the WHO, a series of structures derived from the hydrazone
group were thought of, these were synthesized in this work from reactions involving
isoniazid with aromatic aldehydes in ethanol. These molecules were analyzed by infrared
spectrometry and nuclear magnetic resonance of 13C and 1H isotopes. From them, a new
range of compounds from this hydrazone group were weighed, the oxadiazoles, which,
like the hydrazones, have the most diverse biological applications ever reported in the
technical-scientific literature.
Another issue addressed in this work is the disease caused by the HCV virus, hepatitis C.
This is a disease that infects between 123 and 170 million people around the world and
mainly affects the liver. In search of functionally active molecules against this disease,
1,2,3-triazole compounds are investigated. For the formation of these triazoles, the amino
acid phenylalanine was used, which after reactional processes of esterification, formation
of sulfonamide, alkylation and through the occurrence of "click chemistry" catalyzed by
copper (I), in search of a new triazole not yet reported in the literature. The results will be
properly classified using spectroscopic techniques and sent for biological evaluation at a
later time.

COMMITTEE MEMBERS:
Externo à Instituição - DANIEL TADEU GOMES GONZAGA - UERJ
Presidente - 3652554 - FRANCISCO CANINDE DE SOUSA JUNIOR
Interno - 2276354 - LEANDRO DE SANTIS FERREIRA