Banca de QUALIFICAÇÃO: ANTONIA PEREIRA ROSA NETA
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ANTONIA PEREIRA ROSA NETA
DATE: 31/08/2023
TIME: 08:30
LOCAL: Link de acesso para videoconferência: meet.google.com/sfw-nhuu-gbi
TITLE:
Biomarkers for Arrhythmogenic Right Ventricular Cardiomyopathy: an integrative analysis through bioinformatic
KEY WORDS:
Arrhythmogenic right ventricular cardiomyopathy. ARVC. mRNAs.miRNAs.Biomarkers.
PAGES: 47
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease characterized
pathologically by fibrofatty replacement primarily in the right ventricle of normal heart tissue
and clinically by potentially fatal ventricular arrhythmias in apparently healthy young people.
The prevalence of the disease was estimated at 1:5,000 individuals. ARVC has a very difficult
diagnosis due to the need to investigate and differentiate the results of several
electrocardiographic tests that are also common to other heart diseases. The aim of this work
is to analyze miRNA and mRNA expression profile data from patients with ARVC and
provide insights on the pathophysiology of ARVC and new connections of the miRNAs
mRNAs network for further investigation and screening of efficient biomarkers for ARVC.
For this, GEO dataset databases and bioinformatics tools were used to track 47 DEGs in
ARVC. Then, Gene Ontology enrichment analysis (GO) and protein-protein interaction
analysis (PPI) were performed. Finally, four most important small molecules were identified
that show expression in tissue and plasma and have importance in the disease cycle.
COMMITTEE MEMBERS:
Interno - 1893445 - EUZEBIO GUIMARAES BARBOSA
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Externo à Instituição - OTAVIO CABRAL MARQUES - USP